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• W1762527325 abstract "Case Reports1 August 1957FATAL BROMSULPHALEIN REACTIONH. CHARLES WALKER JR., M.D., MICHAEL F. KOSZALKA, M.D., F.A.C.P.H. CHARLES WALKER JR., M.D.Search for more papers by this author, MICHAEL F. KOSZALKA, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-47-2-362 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptSince the introduction of bromsulphalein as a test for liver function by Rosenthal and White1, 2 approximately 30 years ago, it has come to be considered a safe, innocuous and invaluable diagnostic clinical procedure.3-7 Only rare toxic reactions without serious consequences have occurred.8-13 The purpose of this paper is to report a fatal reaction to bromsulphalein (sulfobromophthalein, U.S.P.; phenoltetrabromphthalein-disodium sulfonate). To our knowledge, this is the first such case to be documented.CASE REPORTA 58 year old married Indian laborer was first hospitalized from April 19, 1955, to May 16, 1955. His complaint at that time was intermittent acute...Bibliography1. RosenthalWhite SMEC: Hepatic function. A. The pharmacologic behavior of certain phthalein dyes. B. The value of selected phthalein compounds in the estimation of hepatic function, J. Pharmacol. and Exper. Therap. 24: 265 (Nov.) 1924. Google Scholar2. RosenthalWhite SMEC: Clinical application of the bromsulphalein test for hepatic function, J. A. M. A. 84: 1112 (Apr. 11) 1925. CrossrefGoogle Scholar3. MateerBaltzMarionMacMillan JGJEDFJM: Liver function tests: general evaluation of liver function tests and appraisal of comparative sensitivity and reliability of newer tests, with particular emphasis on cephalin-cholesterol flocculation test, intravenous hippuric acid test and improved bromsulphthalein test with new normal standard, J. A. M. A. 121: 723 (Mar. 6) 1943. CrossrefGoogle Scholar4. BarkerCappsAllen MHRBFW: Chronic hepatitis in the Mediterranean Theater: new clinical symptoms, J. A. M. A. 129: 653 (Nov. 3) 1945. CrossrefGoogle Scholar5. PopperSteigmannMeyerKozollFranklin HFKADDM: Correlation of liver function and liver structure, Am. J. Med. 6: 278 (Mar.) 1949. CrossrefMedlineGoogle Scholar6. Greene CH: Liver and biliary tract: survey of tests for hepatic function, use of hepatic star in differential diagnosis of jaundice, Arch. Int. Med. 86: 743 (Nov.) 1950. CrossrefGoogle Scholar7. SujeKesslerLisa MBJJR: Clinical, functional and needle biopsy study of the liver in alcoholism, Arch. Int. Med. 86: 658 (Nov.) 1950. CrossrefGoogle Scholar8. ChambersMoister WNFC: Bromsulfalein reaction, Am. J. Med. 5: 308 (Aug.) 1948. CrossrefMedlineGoogle Scholar9. MoreyGabuzdaScudamore GGJHH: Sensitization to bromsulphalein (phenoltetra-bromphthalein-disodium sulfonate), Gastroenterology 13: 246 (Sept.) 1949. MedlineGoogle Scholar10. SieversMoreySamter JJGEM: Fixed anaphylactic sensitization, J. Allergy 20: 76 (Jan.) 1949. CrossrefGoogle Scholar11. Roth JL: Anaphylactoid reaction to sulfobromophthalein sodium, J. A. M. A. 143: 802 (July 1) 1950. CrossrefMedlineGoogle Scholar12. de AndinoMcKeown AMJJ: Unusual toxic reaction to bromsulphalein, Ann. Int. Med. 34: 1265 (May) 1951. LinkGoogle Scholar13. McVay LV: Near fatal reaction to sulfo-bromophthalein (bromsulphalein) liver test, J. A. M. A. 152: 1622 (Aug. 22) 1953. CrossrefMedlineGoogle Scholar14. Brown EA: Problems of drug allergy, J. A. M. A. 159: 814 (Mar. 5) 1955. CrossrefGoogle Scholar15. Flaxman N: Drug fatalities, J. A. M. A. 147: 377 (Sept. 29) 1951. CrossrefMedlineGoogle Scholar16. Meyler L: Side effects of drugs, 1952, Elsevier Publishing Company, New York. Google Scholar17. Barr DP: Hazards of modern diagnosis and therapy—the price we pay, J. A. M. A. 159: 1452 (Dec. 10) 1955. MedlineGoogle Scholar18. RyanShouldice EAEE: Allergy and procaine hydrochloride, J. A. M. A. 152: 1554 (Aug. 15) 1953. CrossrefGoogle Scholar19. BergerEisen AJB: Feasibility of skin testing for penicillin sensitivity, J. A. M. A. 159: 191 (Sept. 17) 1955. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: *Received for publication April 5, 1956.From the Medical Service, Veterans Administration Hospital, Fargo, North Dakota.Requests for reprints should be addressed to Michael F. Koszalka, M.D., Chief, Medical Service, Veterans Administration CenterFargo, North Dakota.†Gross pathology reported by H. Charles Walker, Jr., M.D. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byPreliminary assessment of glycine conjugation of para-aminobenzoic acid as a quantitative test of liver functionNon-Micelle Forming Bile Acids Increase Biliary Gentamicin Excretion in the RatBromsulphthalein reactionAdverse reactions to sulfobromophthalein sodium 1 August 1957Volume 47, Issue 2Page: 362-366KeywordsLiver function testsMedical services ePublished: 1 December 2008 Issue Published: 1 August 1957 PDF downloadLoading ..." @default.
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