Matches in SemOpenAlex for { <https://semopenalex.org/work/W1762806908> ?p ?o ?g. }
Showing items 1 to 77 of
77
with 100 items per page.
- W1762806908 endingPage "302" @default.
- W1762806908 startingPage "297" @default.
- W1762806908 abstract "Plasma levels of follicle-stimulating hormone (FSH), luteinizing hormone (LH), and estradiol (E2) were measured serially in 11 premenopausal patients before and after hysterectomy with bilateral salpingo-oophorectomy. One week after operation an incremental dosage regimen of conjugated estrogens (CEE) in tablet form was commenced on a basis of two weeks with therapy (0.3, 0.625, 1.25, and finally 2.5 mg.), with each dose interspersed by two weeks without therapy. FSH, LH and E2 levels were measured at the end of each period with and without therapy. E2 levels fell within 24 hours of operation while FSH and LH levels rose gradually. CEE therapy produced an elevation of E2, but circulating concentrations comparable to the premenopausal values were only maintained during the dosage periods of 0.625 and 1.25 mg. of CEE. In only one instance did CEE succeed in reducing FSH to premenopausal levels, and that was at a dosage of 2.5 mg., in which instance the E2 level was higher than the premenopausal value. LH was never reduced to a premenopausal level. Thus, the data indicate that CEE alone in dosages up to 2.5 mg. per day was unable to reproduce in postmenopausal women the gonadotropin and E2 blood serum levels whown to exist prior to oophorectomy. Usual CEE treatment after menopause, therefore, in itself does not represent physiologic “hormone replacement therapy,” if defined as the dosage required to maintain premenopausal circulating concentrations of reproductive hormones." @default.
- W1762806908 created "2016-06-24" @default.
- W1762806908 creator A5012992781 @default.
- W1762806908 creator A5031113070 @default.
- W1762806908 creator A5050112725 @default.
- W1762806908 creator A5054248653 @default.
- W1762806908 date "1978-10-01" @default.
- W1762806908 modified "2023-10-16" @default.
- W1762806908 title "Effect of premenopausal castration and incremental dosages of conjugated equine estrogens on plasma follicle-stimulating hormone, luteinizing hormone, and estradiol" @default.
- W1762806908 cites W1974831475 @default.
- W1762806908 cites W2045215854 @default.
- W1762806908 cites W2056854642 @default.
- W1762806908 cites W2057474809 @default.
- W1762806908 cites W2058784613 @default.
- W1762806908 cites W2067829259 @default.
- W1762806908 cites W2091869005 @default.
- W1762806908 cites W2094416739 @default.
- W1762806908 cites W2115730037 @default.
- W1762806908 cites W2158892504 @default.
- W1762806908 cites W2265892161 @default.
- W1762806908 doi "https://doi.org/10.1016/0002-9378(78)90896-7" @default.
- W1762806908 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/212949" @default.
- W1762806908 hasPublicationYear "1978" @default.
- W1762806908 type Work @default.
- W1762806908 sameAs 1762806908 @default.
- W1762806908 citedByCount "29" @default.
- W1762806908 crossrefType "journal-article" @default.
- W1762806908 hasAuthorship W1762806908A5012992781 @default.
- W1762806908 hasAuthorship W1762806908A5031113070 @default.
- W1762806908 hasAuthorship W1762806908A5050112725 @default.
- W1762806908 hasAuthorship W1762806908A5054248653 @default.
- W1762806908 hasConcept C126322002 @default.
- W1762806908 hasConcept C134018914 @default.
- W1762806908 hasConcept C162156334 @default.
- W1762806908 hasConcept C2777164284 @default.
- W1762806908 hasConcept C2778562196 @default.
- W1762806908 hasConcept C2778575703 @default.
- W1762806908 hasConcept C2778782382 @default.
- W1762806908 hasConcept C2779279165 @default.
- W1762806908 hasConcept C2779279991 @default.
- W1762806908 hasConcept C2780159708 @default.
- W1762806908 hasConcept C71315377 @default.
- W1762806908 hasConcept C71924100 @default.
- W1762806908 hasConceptScore W1762806908C126322002 @default.
- W1762806908 hasConceptScore W1762806908C134018914 @default.
- W1762806908 hasConceptScore W1762806908C162156334 @default.
- W1762806908 hasConceptScore W1762806908C2777164284 @default.
- W1762806908 hasConceptScore W1762806908C2778562196 @default.
- W1762806908 hasConceptScore W1762806908C2778575703 @default.
- W1762806908 hasConceptScore W1762806908C2778782382 @default.
- W1762806908 hasConceptScore W1762806908C2779279165 @default.
- W1762806908 hasConceptScore W1762806908C2779279991 @default.
- W1762806908 hasConceptScore W1762806908C2780159708 @default.
- W1762806908 hasConceptScore W1762806908C71315377 @default.
- W1762806908 hasConceptScore W1762806908C71924100 @default.
- W1762806908 hasIssue "3" @default.
- W1762806908 hasLocation W17628069081 @default.
- W1762806908 hasLocation W17628069082 @default.
- W1762806908 hasOpenAccess W1762806908 @default.
- W1762806908 hasPrimaryLocation W17628069081 @default.
- W1762806908 hasRelatedWork W1572148158 @default.
- W1762806908 hasRelatedWork W2000170411 @default.
- W1762806908 hasRelatedWork W2024649280 @default.
- W1762806908 hasRelatedWork W2063235021 @default.
- W1762806908 hasRelatedWork W2067304466 @default.
- W1762806908 hasRelatedWork W2145229803 @default.
- W1762806908 hasRelatedWork W2163840050 @default.
- W1762806908 hasRelatedWork W2468044930 @default.
- W1762806908 hasRelatedWork W3118753040 @default.
- W1762806908 hasRelatedWork W2006611219 @default.
- W1762806908 hasVolume "132" @default.
- W1762806908 isParatext "false" @default.
- W1762806908 isRetracted "false" @default.
- W1762806908 magId "1762806908" @default.
- W1762806908 workType "article" @default.