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- W1763082601 abstract "The peroxisome proliferator‐activated receptors, PPAR α, PPAR β/δ and PPAR γ, are ligand‐activated transcriptional factors belonging to the nuclear receptors superfamily and they are known to play important roles in glucose and lipid metabolism. Experimental studies in animal models of metabolic diseases have also revealed that activation of PPAR s protects against the vascular complications of diabetes, hypertension, atherosclerosis, myocardial infarction and stroke, through exerting their anti‐inflammatory, anti‐atherogenic and antioxidant effects. In clinical trials and post‐market surveillance, agonists of PPAR s have been shown to effectively prevent cardiovascular events. However, adverse effects, particularly for PPAR γ agonists, are also observed with the use of investigational PPAR agonists and even some approved drugs. Further exploration of underlying mechanisms is needed to develop novel ways of PPAR activation without causing serious side effects. This article reviews the cardiovascular effects of PPAR s, with emphasis on the therapeutic potential of PPAR agonists in combating metabolic vascular diseases. Linked Articles This article is part of a themed section on Chinese Innovation in Cardiovascular Drug Discovery. To view the other articles in this section visit http://dx.doi.org/10.1111/bph.2015.172.issue-23" @default.
- W1763082601 created "2016-06-24" @default.
- W1763082601 creator A5012312094 @default.
- W1763082601 creator A5015080274 @default.
- W1763082601 creator A5019246193 @default.
- W1763082601 creator A5021520609 @default.
- W1763082601 date "2015-01-23" @default.
- W1763082601 modified "2023-10-17" @default.
- W1763082601 title "The peroxisome proliferator-activated receptors in cardiovascular diseases: experimental benefits and clinical challenges" @default.
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