Matches in SemOpenAlex for { <https://semopenalex.org/work/W176308265> ?p ?o ?g. }
- W176308265 endingPage "162" @default.
- W176308265 startingPage "099" @default.
- W176308265 abstract "Maintenance of genomic integrity is essential to avoid cellular transformation, neoplasia, or cell death. DNA synthesis, mitosis, and cytokinesis are important cellular processes required for cell division and the maintenance of cellular homeostasis; they are governed by many extra- and intra-cellular stimuli. Progression of normal cell division depends on cyclin interaction with cyclin-dependent kinases (Cdk) and the degradation of cyclins before chromosomal segregation through ubiquitination. Multiple checkpoints exist and are conserved in the cell cycle in higher eukaryotes to ensure that if one fails, others will take care of genomic integrity and cell survival. Many genes act as either positive or negative regulators of checkpoint function through different kinase cascades, delaying cell cycle progression to repair the DNA lesions and breaks, and assuring equal segregation of chromosomes to daughter cells. Understanding the checkpoint pathways and genes involved in the cellular response to DNA damage and cell division events in normal and cancer cells, provides information about cancer predisposition, and suggests design of small molecules and other strategies for cancer therapy." @default.
- W176308265 created "2016-06-24" @default.
- W176308265 creator A5030561689 @default.
- W176308265 creator A5075201353 @default.
- W176308265 date "2004-06-08" @default.
- W176308265 modified "2023-09-27" @default.
- W176308265 title "Cell Cycle Checkpoint Control Mechanisms That Can Be Disrupted in Cancer" @default.
- W176308265 cites W103445271 @default.
- W176308265 cites W1480741751 @default.
- W176308265 cites W1482130018 @default.
- W176308265 cites W1488719611 @default.
- W176308265 cites W1493317669 @default.
- W176308265 cites W1495729285 @default.
- W176308265 cites W149894293 @default.
- W176308265 cites W1504970629 @default.
- W176308265 cites W1506793089 @default.
- W176308265 cites W1508230049 @default.
- W176308265 cites W1513261706 @default.
- W176308265 cites W1520424015 @default.
- W176308265 cites W1520947267 @default.
- W176308265 cites W1537737236 @default.
- W176308265 cites W1540858422 @default.
- W176308265 cites W1541806623 @default.
- W176308265 cites W1544512904 @default.
- W176308265 cites W1544564404 @default.
- W176308265 cites W1545084887 @default.
- W176308265 cites W1558485979 @default.
- W176308265 cites W1566217027 @default.
- W176308265 cites W1566625041 @default.
- W176308265 cites W1569698611 @default.
- W176308265 cites W1594985705 @default.
- W176308265 cites W1597405508 @default.
- W176308265 cites W1602446144 @default.
- W176308265 cites W1618806168 @default.
- W176308265 cites W1635667563 @default.
- W176308265 cites W1650797637 @default.
- W176308265 cites W165254100 @default.
- W176308265 cites W1657157395 @default.
- W176308265 cites W1661087247 @default.
- W176308265 cites W1665024321 @default.
- W176308265 cites W1677118171 @default.
- W176308265 cites W1752089945 @default.
- W176308265 cites W1778446120 @default.
- W176308265 cites W1886278373 @default.
- W176308265 cites W1903850103 @default.
- W176308265 cites W1905446558 @default.
- W176308265 cites W1937607074 @default.
- W176308265 cites W1952982568 @default.
- W176308265 cites W1962321933 @default.
- W176308265 cites W1963648581 @default.
- W176308265 cites W1966383348 @default.
- W176308265 cites W1966567462 @default.
- W176308265 cites W1967071341 @default.
- W176308265 cites W1967743500 @default.
- W176308265 cites W1968687444 @default.
- W176308265 cites W1968863900 @default.
- W176308265 cites W1970591729 @default.
- W176308265 cites W1970698977 @default.
- W176308265 cites W1970783685 @default.
- W176308265 cites W1972305847 @default.
- W176308265 cites W1974391793 @default.
- W176308265 cites W1974559056 @default.
- W176308265 cites W1975622188 @default.
- W176308265 cites W1976558883 @default.
- W176308265 cites W1980561563 @default.
- W176308265 cites W1981524094 @default.
- W176308265 cites W1982061874 @default.
- W176308265 cites W1983210070 @default.
- W176308265 cites W1983255679 @default.
- W176308265 cites W1984012038 @default.
- W176308265 cites W1984544266 @default.
- W176308265 cites W1985046929 @default.
- W176308265 cites W1987767376 @default.
- W176308265 cites W1988678729 @default.
- W176308265 cites W1988864144 @default.
- W176308265 cites W1989394815 @default.
- W176308265 cites W1989420337 @default.
- W176308265 cites W1989478892 @default.
- W176308265 cites W1990512216 @default.
- W176308265 cites W1990750564 @default.
- W176308265 cites W1992630665 @default.
- W176308265 cites W1994211401 @default.
- W176308265 cites W1994949503 @default.
- W176308265 cites W1995405908 @default.
- W176308265 cites W1995842427 @default.
- W176308265 cites W1996172944 @default.
- W176308265 cites W1996413533 @default.
- W176308265 cites W1996505651 @default.
- W176308265 cites W1996931202 @default.
- W176308265 cites W1997439972 @default.
- W176308265 cites W1998682793 @default.
- W176308265 cites W1998947396 @default.
- W176308265 cites W1999549596 @default.
- W176308265 cites W2000285763 @default.
- W176308265 cites W2001537741 @default.
- W176308265 cites W2003282728 @default.
- W176308265 cites W2003379794 @default.
- W176308265 cites W2004008931 @default.