Matches in SemOpenAlex for { <https://semopenalex.org/work/W1763663365> ?p ?o ?g. }
Showing items 1 to 92 of
92
with 100 items per page.
- W1763663365 endingPage "8" @default.
- W1763663365 startingPage "3663" @default.
- W1763663365 abstract "Perivascular epithelioid cell tumors (PEComas) are rare tumors driven by tuberous sclerosis complex gene mutations causing up-regulation of mTOR. We report the outcome of ten consecutive patients treated with sirolimus or temsirolimus.A retrospective analysis was performed on patients seen between 2007 and 2013. Demographic and treatment data were collected and radiological response was assessed.Ten patients were investigated, eight females, with median age of 47.5 years. Nine patients received sirolimus, one temsirolimus. The median treatment duration was 128 (range=7-1,366 days). Temsirolimus was given at 25 mg IV weekly and median starting dose of sirolimus was 3 mg daily. Seven patients were evaluable for response by RECIST: 5 showed partial response (50%), 1 stable disease (10%) and 1 progressive disease (10%). Two patients progressed rapidly on treatment. One patient stopped due to grade 3 hyperlipidaemia although CT scan shows maintained response. Three patients continue on treatment while the remainder stopped due to disease progression.Our study confirms that mTOR inhibition with sirolimus/temsirolimus is well-tolerated with good radiological responses, albeit short-lived, and supports its use in PEComas." @default.
- W1763663365 created "2016-06-24" @default.
- W1763663365 creator A5003031523 @default.
- W1763663365 creator A5007158398 @default.
- W1763663365 creator A5025253619 @default.
- W1763663365 creator A5034433849 @default.
- W1763663365 creator A5045446273 @default.
- W1763663365 creator A5046385124 @default.
- W1763663365 creator A5053304892 @default.
- W1763663365 creator A5056339622 @default.
- W1763663365 creator A5076054848 @default.
- W1763663365 creator A5084162980 @default.
- W1763663365 date "2014-07-01" @default.
- W1763663365 modified "2023-10-03" @default.
- W1763663365 title "A retrospective study of patients with malignant PEComa receiving treatment with sirolimus or temsirolimus: the Royal Marsden Hospital experience." @default.
- W1763663365 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24982384" @default.
- W1763663365 hasPublicationYear "2014" @default.
- W1763663365 type Work @default.
- W1763663365 sameAs 1763663365 @default.
- W1763663365 citedByCount "30" @default.
- W1763663365 countsByYear W17636633652014 @default.
- W1763663365 countsByYear W17636633652015 @default.
- W1763663365 countsByYear W17636633652016 @default.
- W1763663365 countsByYear W17636633652017 @default.
- W1763663365 countsByYear W17636633652018 @default.
- W1763663365 countsByYear W17636633652019 @default.
- W1763663365 countsByYear W17636633652020 @default.
- W1763663365 countsByYear W17636633652021 @default.
- W1763663365 countsByYear W17636633652022 @default.
- W1763663365 countsByYear W17636633652023 @default.
- W1763663365 crossrefType "journal-article" @default.
- W1763663365 hasAuthorship W1763663365A5003031523 @default.
- W1763663365 hasAuthorship W1763663365A5007158398 @default.
- W1763663365 hasAuthorship W1763663365A5025253619 @default.
- W1763663365 hasAuthorship W1763663365A5034433849 @default.
- W1763663365 hasAuthorship W1763663365A5045446273 @default.
- W1763663365 hasAuthorship W1763663365A5046385124 @default.
- W1763663365 hasAuthorship W1763663365A5053304892 @default.
- W1763663365 hasAuthorship W1763663365A5056339622 @default.
- W1763663365 hasAuthorship W1763663365A5076054848 @default.
- W1763663365 hasAuthorship W1763663365A5084162980 @default.
- W1763663365 hasConcept C126322002 @default.
- W1763663365 hasConcept C141071460 @default.
- W1763663365 hasConcept C142724271 @default.
- W1763663365 hasConcept C167135981 @default.
- W1763663365 hasConcept C183713625 @default.
- W1763663365 hasConcept C190283241 @default.
- W1763663365 hasConcept C2776820818 @default.
- W1763663365 hasConcept C2777921159 @default.
- W1763663365 hasConcept C2778822529 @default.
- W1763663365 hasConcept C2778980267 @default.
- W1763663365 hasConcept C2779134260 @default.
- W1763663365 hasConcept C55493867 @default.
- W1763663365 hasConcept C71924100 @default.
- W1763663365 hasConcept C86554907 @default.
- W1763663365 hasConcept C86803240 @default.
- W1763663365 hasConceptScore W1763663365C126322002 @default.
- W1763663365 hasConceptScore W1763663365C141071460 @default.
- W1763663365 hasConceptScore W1763663365C142724271 @default.
- W1763663365 hasConceptScore W1763663365C167135981 @default.
- W1763663365 hasConceptScore W1763663365C183713625 @default.
- W1763663365 hasConceptScore W1763663365C190283241 @default.
- W1763663365 hasConceptScore W1763663365C2776820818 @default.
- W1763663365 hasConceptScore W1763663365C2777921159 @default.
- W1763663365 hasConceptScore W1763663365C2778822529 @default.
- W1763663365 hasConceptScore W1763663365C2778980267 @default.
- W1763663365 hasConceptScore W1763663365C2779134260 @default.
- W1763663365 hasConceptScore W1763663365C55493867 @default.
- W1763663365 hasConceptScore W1763663365C71924100 @default.
- W1763663365 hasConceptScore W1763663365C86554907 @default.
- W1763663365 hasConceptScore W1763663365C86803240 @default.
- W1763663365 hasIssue "7" @default.
- W1763663365 hasLocation W17636633651 @default.
- W1763663365 hasOpenAccess W1763663365 @default.
- W1763663365 hasPrimaryLocation W17636633651 @default.
- W1763663365 hasRelatedWork W1763663365 @default.
- W1763663365 hasRelatedWork W2004900348 @default.
- W1763663365 hasRelatedWork W2027203907 @default.
- W1763663365 hasRelatedWork W2076274224 @default.
- W1763663365 hasRelatedWork W2283392268 @default.
- W1763663365 hasRelatedWork W2890558484 @default.
- W1763663365 hasRelatedWork W2908097512 @default.
- W1763663365 hasRelatedWork W4206161940 @default.
- W1763663365 hasRelatedWork W4221087066 @default.
- W1763663365 hasRelatedWork W2781008247 @default.
- W1763663365 hasVolume "34" @default.
- W1763663365 isParatext "false" @default.
- W1763663365 isRetracted "false" @default.
- W1763663365 magId "1763663365" @default.
- W1763663365 workType "article" @default.