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- W1764134453 abstract "Severe infections with Streptococcus pyogenes, an important human pathogen, are associated with massive inflammatory reactions in the human host. Here we show that streptococcal M protein interacts with TLR2 on human peripheral blood monocytes. As a consequence, monocytes express the cytokines IL-6, IL-1β, and TNF-α. This response is significantly increased in the presence of neutrophil-derived heparin-binding protein (HBP), which costimulates monocytes by interacting with CD11/CD18. Analysis of tissue biopsies from patients with necrotizing fasciitis revealed recruitment of neutrophils and monocytes to the infectious site, combined with the release of HBP. The results show that M protein, in synergy with HBP, evokes an inflammatory response that may contribute to the profound pathophysiological consequences seen in severe streptococcal infections." @default.
- W1764134453 created "2016-06-24" @default.
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- W1764134453 date "2006-07-03" @default.
- W1764134453 modified "2023-10-16" @default.
- W1764134453 title "Streptococcal M Protein: A Multipotent and Powerful Inducer of Inflammation" @default.
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- W1764134453 doi "https://doi.org/10.4049/jimmunol.177.2.1221" @default.
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