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- W1764646618 abstract "Thirteen women with either cervical or endometrial carcinoma or choriocarcinoma were given nitrogen or phenylalanine mustard. Leukopenia, pancytopenia, and anemia occurred in varying degrees of severity in different patients; two women died of sepsis during or shortly after the most acute phase of bone marrow depression. A third person acquired permanent partial motor paralysis of both legs from neurotoxic effects. The intrapelvic soft tissues were “frozen” in the fourth patient by the radiomimetic action of nitrogen mustard. Only those with endometrial carcinoma and with an initial favorable prognosis were living 2 years later. It is our present opinion that the undesirable toxic effects of the drugs outweigh the beneficial amelioration for these particular tumors, given in the manner and dosages described here." @default.
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- W1764646618 date "1962-02-01" @default.
- W1764646618 modified "2023-09-26" @default.
- W1764646618 title "Nitrogen and phenylalanine mustard" @default.
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- W1764646618 doi "https://doi.org/10.1016/0002-9378(62)90583-5" @default.
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