Matches in SemOpenAlex for { <https://semopenalex.org/work/W1765103683> ?p ?o ?g. }
Showing items 1 to 66 of
66
with 100 items per page.
- W1765103683 endingPage "227" @default.
- W1765103683 startingPage "219" @default.
- W1765103683 abstract "ABSTRACT Earlier studies in our laboratory indicated the predominance of pentose cycle activity in early embryos (Jolley, Cheldelin & Newburgh, 1959; Coffey, 1963). In addition a correlation was demonstrated between enzymes generating reduced triphosphopyridine nucleotide and lipid synthesis (Bieber, Cheldelin & Newburgh, 1962; Baker & Newburgh, 1963). Since several of the biosynthetic pathways involve this compound, it is conceivable that in a rapidly growing system such as the early chick embryo enzymes generating TPNH may play a major röle. We have chosen to use explants of chick embryos in an attempt to gain insight into the relation of changes of these enzymes with other chemical changes which may more directly relate to differentiation. These latter changes include synthesis of such macromolecules as DNA, RNA, hemoglobin, collagen and myosin. This method permits the addition of certain chemicals to the media such as substrates or inhibitors (Hayashi et al., 1959), allowing easy manipulation of the environment. Prior to studying the above macromolecules it seemed appropriate to study the effect of certain inhibitors on glucose-6-phosphate, 6-phosphogluconic acid and isocitric dehydrogenase. It was hoped that such information might be useful for purposes of establishing base lines of biochemical activity. The inhibitors chosen were fluorouracil, chloramphenicol and acetyl pyridine, and it will be shown that these had several rather specific effects on the enzymes studied. The first two inhibitors were chosen because of their relation to RNA or protein biosynthesis and the latter since it is an analogue of the pyridine moiety of TPN." @default.
- W1765103683 created "2016-06-24" @default.
- W1765103683 creator A5022189335 @default.
- W1765103683 creator A5061663440 @default.
- W1765103683 creator A5078797157 @default.
- W1765103683 creator A5089364380 @default.
- W1765103683 date "1964-06-01" @default.
- W1765103683 modified "2023-09-26" @default.
- W1765103683 title "Effect of various inhibitors on several enzymes and other biochemical substances in chick embryo explants" @default.
- W1765103683 cites W1584879362 @default.
- W1765103683 cites W1906197854 @default.
- W1765103683 cites W1942172751 @default.
- W1765103683 cites W1972828987 @default.
- W1765103683 cites W2001415635 @default.
- W1765103683 cites W2002767779 @default.
- W1765103683 cites W2058452771 @default.
- W1765103683 cites W2064486592 @default.
- W1765103683 cites W2140034535 @default.
- W1765103683 cites W2322361539 @default.
- W1765103683 doi "https://doi.org/10.1242/dev.12.2.219" @default.
- W1765103683 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14192047" @default.
- W1765103683 hasPublicationYear "1964" @default.
- W1765103683 type Work @default.
- W1765103683 sameAs 1765103683 @default.
- W1765103683 citedByCount "1" @default.
- W1765103683 crossrefType "journal-article" @default.
- W1765103683 hasAuthorship W1765103683A5022189335 @default.
- W1765103683 hasAuthorship W1765103683A5061663440 @default.
- W1765103683 hasAuthorship W1765103683A5078797157 @default.
- W1765103683 hasAuthorship W1765103683A5089364380 @default.
- W1765103683 hasConcept C104317684 @default.
- W1765103683 hasConcept C181199279 @default.
- W1765103683 hasConcept C196843134 @default.
- W1765103683 hasConcept C55493867 @default.
- W1765103683 hasConcept C67705224 @default.
- W1765103683 hasConcept C86803240 @default.
- W1765103683 hasConcept C95444343 @default.
- W1765103683 hasConceptScore W1765103683C104317684 @default.
- W1765103683 hasConceptScore W1765103683C181199279 @default.
- W1765103683 hasConceptScore W1765103683C196843134 @default.
- W1765103683 hasConceptScore W1765103683C55493867 @default.
- W1765103683 hasConceptScore W1765103683C67705224 @default.
- W1765103683 hasConceptScore W1765103683C86803240 @default.
- W1765103683 hasConceptScore W1765103683C95444343 @default.
- W1765103683 hasIssue "2" @default.
- W1765103683 hasLocation W17651036831 @default.
- W1765103683 hasLocation W17651036832 @default.
- W1765103683 hasOpenAccess W1765103683 @default.
- W1765103683 hasPrimaryLocation W17651036831 @default.
- W1765103683 hasRelatedWork W1892544028 @default.
- W1765103683 hasRelatedWork W1970709224 @default.
- W1765103683 hasRelatedWork W2005627939 @default.
- W1765103683 hasRelatedWork W2047779449 @default.
- W1765103683 hasRelatedWork W2138547054 @default.
- W1765103683 hasRelatedWork W2169340257 @default.
- W1765103683 hasRelatedWork W2415301716 @default.
- W1765103683 hasRelatedWork W2509789438 @default.
- W1765103683 hasRelatedWork W2596000028 @default.
- W1765103683 hasRelatedWork W2596232480 @default.
- W1765103683 hasVolume "12" @default.
- W1765103683 isParatext "false" @default.
- W1765103683 isRetracted "false" @default.
- W1765103683 magId "1765103683" @default.
- W1765103683 workType "article" @default.