FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1765205393> ?p ?o ?g. }

• W1765205393 endingPage "279" @default.
• W1765205393 startingPage "273" @default.
• W1765205393 abstract "Genistein (GEN), a major soybean isoflavone (SIF), might possess neuroprotective properties through its anti-inflammatory activity. We hypothesized that GEN could prevent the inflammatory damage detected in C6 cells induced by β-amyloid peptides 25-35 (Aβ25-35). Accordingly, we evaluated the inflammatory damage induced by Aβ25-35 and the protective effect of GEN against Aβ25-35 in C6 cells. In our study, the C6 glial cells (rats glioma cell lines) were preincubated with or without GEN for 2 h following incubation with Aβ25-35 for another 24 h. Then, methylthiazolyl tetrazolium (MTT) assay was used to assess the cell viability. Immunofluorescence staining was used to identify the C6 cells. Inflammatory factors tumor necrosis factor (TNF)-α and interleukin (IL)-1β were analyzed by using enzyme-linked immunosorbent assay (ELISA). Western blot analysis and reverse transcription-polymerase chain reaction analysis were performed to assess the expression of Toll-like receptors 4 (TLR4), inhibitor of kappaB-alpha (IκB-α). The current results showed that GEN could alleviate Aβ25-35-induced cell apoptosis and prevent Aβ25-35-induced TNF-α and IL-1β release from C6 cells. In addition, GEN prevented Aβ25-35-induced upregulation of the gene and protein expression of TLR4, and GEN significantly upregulated the expression of IκB-α in C6 cells damaged by Aβ25-35. These results suggest that GEN can alleviate the inflammatory stress caused by Aβ25-35 treatment, which might be associated with the neuroprotective effect of GEN regulating the TLR4/NFκB signaling pathway." @default.
• W1765205393 created "2016-06-24" @default.
• W1765205393 creator A5008636823 @default.
• W1765205393 creator A5043864362 @default.
• W1765205393 creator A5060353579 @default.
• W1765205393 creator A5072597095 @default.
• W1765205393 creator A5075206070 @default.
• W1765205393 creator A5088693287 @default.
• W1765205393 date "2015-03-01" @default.
• W1765205393 modified "2023-09-23" @default.
• W1765205393 title "Genistein Alleviates <i>β</i>-Amyloid-Induced Inflammatory Damage Through Regulating Toll-Like Receptor 4/Nuclear Factor <i>κ</i>B" @default.
• W1765205393 cites W1975151442 @default.
• W1765205393 cites W1975257515 @default.
• W1765205393 cites W1980485769 @default.
• W1765205393 cites W1995784269 @default.
• W1765205393 cites W1999584554 @default.
• W1765205393 cites W2004508336 @default.
• W1765205393 cites W2015668522 @default.
• W1765205393 cites W2018867961 @default.
• W1765205393 cites W2022955088 @default.
• W1765205393 cites W2039068134 @default.
• W1765205393 cites W2041157249 @default.
• W1765205393 cites W2043679754 @default.
• W1765205393 cites W2046727734 @default.
• W1765205393 cites W2050897729 @default.
• W1765205393 cites W2058747572 @default.
• W1765205393 cites W2068649643 @default.
• W1765205393 cites W2069905837 @default.
• W1765205393 cites W2070607774 @default.
• W1765205393 cites W2076260194 @default.
• W1765205393 cites W2077824737 @default.
• W1765205393 cites W2082429191 @default.
• W1765205393 cites W2082890018 @default.
• W1765205393 cites W2091273694 @default.
• W1765205393 cites W2091385151 @default.
• W1765205393 cites W2094863064 @default.
• W1765205393 cites W2095013915 @default.
• W1765205393 cites W2099171820 @default.
• W1765205393 cites W2110793063 @default.
• W1765205393 cites W2119984655 @default.
• W1765205393 cites W2122469170 @default.
• W1765205393 cites W2125113206 @default.
• W1765205393 cites W2144679012 @default.
• W1765205393 cites W2148119611 @default.
• W1765205393 cites W2156993661 @default.
• W1765205393 cites W2158980170 @default.
• W1765205393 cites W2160691931 @default.
• W1765205393 cites W2613217394 @default.
• W1765205393 doi "https://doi.org/10.1089/jmf.2014.3150" @default.
• W1765205393 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4350449" @default.
• W1765205393 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25384233" @default.
• W1765205393 hasPublicationYear "2015" @default.
• W1765205393 type Work @default.
• W1765205393 sameAs 1765205393 @default.
• W1765205393 citedByCount "29" @default.
• W1765205393 countsByYear W17652053932015 @default.
• W1765205393 countsByYear W17652053932016 @default.
• W1765205393 countsByYear W17652053932017 @default.
• W1765205393 countsByYear W17652053932018 @default.
• W1765205393 countsByYear W17652053932019 @default.
• W1765205393 countsByYear W17652053932020 @default.
• W1765205393 countsByYear W17652053932021 @default.
• W1765205393 countsByYear W17652053932022 @default.
• W1765205393 countsByYear W17652053932023 @default.
• W1765205393 crossrefType "journal-article" @default.
• W1765205393 hasAuthorship W1765205393A5008636823 @default.
• W1765205393 hasAuthorship W1765205393A5043864362 @default.
• W1765205393 hasAuthorship W1765205393A5060353579 @default.
• W1765205393 hasAuthorship W1765205393A5072597095 @default.
• W1765205393 hasAuthorship W1765205393A5075206070 @default.
• W1765205393 hasAuthorship W1765205393A5088693287 @default.
• W1765205393 hasBestOaLocation W17652053932 @default.
• W1765205393 hasConcept C104317684 @default.
• W1765205393 hasConcept C127561419 @default.
• W1765205393 hasConcept C134018914 @default.
• W1765205393 hasConcept C153911025 @default.
• W1765205393 hasConcept C170493617 @default.
• W1765205393 hasConcept C17991360 @default.
• W1765205393 hasConcept C185592680 @default.
• W1765205393 hasConcept C190283241 @default.
• W1765205393 hasConcept C203014093 @default.
• W1765205393 hasConcept C25498285 @default.
• W1765205393 hasConcept C2776070231 @default.
• W1765205393 hasConcept C2776415932 @default.
• W1765205393 hasConcept C2776914184 @default.
• W1765205393 hasConcept C2778298627 @default.
• W1765205393 hasConcept C2778690821 @default.
• W1765205393 hasConcept C2779830541 @default.
• W1765205393 hasConcept C2781236682 @default.
• W1765205393 hasConcept C53227056 @default.
• W1765205393 hasConcept C55493867 @default.
• W1765205393 hasConcept C74172505 @default.
• W1765205393 hasConcept C86803240 @default.
• W1765205393 hasConcept C98274493 @default.
• W1765205393 hasConceptScore W1765205393C104317684 @default.
• W1765205393 hasConceptScore W1765205393C127561419 @default.
• W1765205393 hasConceptScore W1765205393C134018914 @default.
• W1765205393 hasConceptScore W1765205393C153911025 @default.

• next