Matches in SemOpenAlex for { <https://semopenalex.org/work/W176528573> ?p ?o ?g. }
Showing items 1 to 84 of
84
with 100 items per page.
- W176528573 endingPage "90" @default.
- W176528573 startingPage "86" @default.
- W176528573 abstract "Abnormal bleeding after cardiopulmonary bypass (CPB) may result from incomplete neutralization of heparin, increased fibrinolytic activity, consumption of coagulation factors, or from a reduction in the number of circulating platelets together with impairment of platelet function. Although researchers have reason to believe that hemostasis after CPB could be improved with prostacyclin (PGI(2)), a potent inhibitor of platelet aggregation, the drug's clear-cut benefits in this respect have not yet been confirmed. After conducting an initial study concerning the fate of platelets during CPB, in which we determined that PGI(2) had a protective effect, we investigated the effects of PGI(2) infusion during CPB on postoperative blood loss in 554 open-heart surgery patients, 200 of whom underwent valve replacement, 200 of whom had coronary artery bypass grafting (CABG), and 154 of whom underwent repeat valve replacement or CABG. The patients were divided into 2 groups: 277 patients (the study group) received both heparin and PGI(2) during CPB, whereas the remaining 277 patients (the control group) were given heparin alone. Of the patients who underwent surgery for the first time, those treated with PGI(2) had a reduced mean blood loss (p < 0.05 only in CABG patients) in comparison with those who received heparin alone. Of the patients who underwent redo operations, those who received PGI(2) had a nonsignificant tendency toward reduced blood loss. The mean difference in blood loss between the study group and the control group had no clinical relevance, however, because it was less than the smallest practical unit of measurement (i.e., 1 unit of blood)." @default.
- W176528573 created "2016-06-24" @default.
- W176528573 creator A5002467492 @default.
- W176528573 creator A5004868898 @default.
- W176528573 creator A5045785598 @default.
- W176528573 creator A5062882537 @default.
- W176528573 creator A5080686515 @default.
- W176528573 creator A5085297093 @default.
- W176528573 date "1988-01-01" @default.
- W176528573 modified "2023-09-26" @default.
- W176528573 title "A prospective study of the clinical benefits of prostacyclin in 554 cardiopulmonary bypass procedures." @default.
- W176528573 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/324797" @default.
- W176528573 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15227257" @default.
- W176528573 hasPublicationYear "1988" @default.
- W176528573 type Work @default.
- W176528573 sameAs 176528573 @default.
- W176528573 citedByCount "0" @default.
- W176528573 crossrefType "journal-article" @default.
- W176528573 hasAuthorship W176528573A5002467492 @default.
- W176528573 hasAuthorship W176528573A5004868898 @default.
- W176528573 hasAuthorship W176528573A5045785598 @default.
- W176528573 hasAuthorship W176528573A5062882537 @default.
- W176528573 hasAuthorship W176528573A5080686515 @default.
- W176528573 hasAuthorship W176528573A5085297093 @default.
- W176528573 hasConcept C126322002 @default.
- W176528573 hasConcept C141071460 @default.
- W176528573 hasConcept C164705383 @default.
- W176528573 hasConcept C2775901492 @default.
- W176528573 hasConcept C2776820930 @default.
- W176528573 hasConcept C2777557582 @default.
- W176528573 hasConcept C2778589496 @default.
- W176528573 hasConcept C2778881276 @default.
- W176528573 hasConcept C2780007028 @default.
- W176528573 hasConcept C2780026749 @default.
- W176528573 hasConcept C2781128415 @default.
- W176528573 hasConcept C42219234 @default.
- W176528573 hasConcept C71924100 @default.
- W176528573 hasConcept C89560881 @default.
- W176528573 hasConceptScore W176528573C126322002 @default.
- W176528573 hasConceptScore W176528573C141071460 @default.
- W176528573 hasConceptScore W176528573C164705383 @default.
- W176528573 hasConceptScore W176528573C2775901492 @default.
- W176528573 hasConceptScore W176528573C2776820930 @default.
- W176528573 hasConceptScore W176528573C2777557582 @default.
- W176528573 hasConceptScore W176528573C2778589496 @default.
- W176528573 hasConceptScore W176528573C2778881276 @default.
- W176528573 hasConceptScore W176528573C2780007028 @default.
- W176528573 hasConceptScore W176528573C2780026749 @default.
- W176528573 hasConceptScore W176528573C2781128415 @default.
- W176528573 hasConceptScore W176528573C42219234 @default.
- W176528573 hasConceptScore W176528573C71924100 @default.
- W176528573 hasConceptScore W176528573C89560881 @default.
- W176528573 hasIssue "2" @default.
- W176528573 hasLocation W1765285731 @default.
- W176528573 hasLocation W1765285732 @default.
- W176528573 hasOpenAccess W176528573 @default.
- W176528573 hasPrimaryLocation W1765285731 @default.
- W176528573 hasRelatedWork W1479812680 @default.
- W176528573 hasRelatedWork W1560506430 @default.
- W176528573 hasRelatedWork W1974932585 @default.
- W176528573 hasRelatedWork W2026869884 @default.
- W176528573 hasRelatedWork W2041187974 @default.
- W176528573 hasRelatedWork W2062523207 @default.
- W176528573 hasRelatedWork W2071592148 @default.
- W176528573 hasRelatedWork W2073600035 @default.
- W176528573 hasRelatedWork W2078363418 @default.
- W176528573 hasRelatedWork W2095683062 @default.
- W176528573 hasRelatedWork W2123785333 @default.
- W176528573 hasRelatedWork W2133463223 @default.
- W176528573 hasRelatedWork W2184218841 @default.
- W176528573 hasRelatedWork W2270217222 @default.
- W176528573 hasRelatedWork W2321744597 @default.
- W176528573 hasRelatedWork W2394998211 @default.
- W176528573 hasRelatedWork W2484059125 @default.
- W176528573 hasRelatedWork W2588474259 @default.
- W176528573 hasRelatedWork W2792454803 @default.
- W176528573 hasRelatedWork W2886888258 @default.
- W176528573 hasVolume "15" @default.
- W176528573 isParatext "false" @default.
- W176528573 isRetracted "false" @default.
- W176528573 magId "176528573" @default.
- W176528573 workType "article" @default.