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- W1765419236 abstract "We have been studying the mechanisms whereby pools of motor neurons establish a rostrocaudal bias in the position of their synapses in some skeletal muscles. The serratus anterior (SA) muscle of the rat displays a rostrocaudal topographic map before birth, and the topography is re-established after denervation. In this report, we explore the potential role of synaptic competition between innervating axons as a means of generating topographic specificity. We followed the progress of the reformation of this map in neonatal animals under conditions that enhanced the likelihood of observing synaptic competition. This was accomplished by forcing caudal axons to regenerate ahead of rostral axons onto a surgically reduced SA muscle. In this way, caudal (C 7 ) motor neurons had unopposed access to vacated synaptic sites on the remaining rostral half of the SA before the return of the rostral (C 6 ) axons. Intracellular recording revealed that 2 d after the second denervation, most of the reinnervated end plates contained only axons from the C 7 branch; the remaining reinnervated end plates received input from C 6 only or were multiply innervated by C 6 and C 7 axons. After 6 d, the pattern was reversed, with most end plates innervated exclusively by C 6 . After 17 d, axons from C 6 were the sole input to reinnervated end plates. During the transition from C 7 - to C 6 -dominated input, at end plates coinnervated by C 6 and C 7 axons, the average quantal content from C 6 was the same as that from C 7 ; after 7 d, the quantal content of C 6 was greater than that of C 7 . We have thus developed an experimental situation in which the outcome of synaptic competition is predictable and can be influenced by the positional labels associated with axons from different levels in the spinal cord." @default.
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- W1765419236 date "1998-09-15" @default.
- W1765419236 modified "2023-10-13" @default.
- W1765419236 title "Synaptic Competition during the Reformation of a Neuromuscular Map" @default.
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- W1765419236 doi "https://doi.org/10.1523/jneurosci.18-18-07328.1998" @default.
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