FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1765617305> ?p ?o ?g. }

• W1765617305 endingPage "937" @default.
• W1765617305 startingPage "930" @default.
• W1765617305 abstract "Previous studies have indicated that immunoglobulin enhancers are essential for establishing transcriptional competence but not for maintaining the activity of constitutively transcribed genes. To understand the basis for this developmental shift away from dependence on enhancer function, we have investigated the relationship between transcriptional activity and methylation status of the immunoglobulin kappa light-chain genes (kappa genes) in mouse cell lines representing different stages of B-cell maturation. Using pre-B-cell lines in which the level of a critical kappa enhancer-binding factor, NF-kappa B, was controlled by the administration or withdrawal of lipopolysaccharide and plasmacytoma lines that either contain or lack this factor, we studied the properties of endogenous kappa genes and of transfected kappa genes which were stably integrated into the genomes of these cells. In the pre-B cells, the exogenous (originally unmethylated) kappa genes, as well as endogenous kappa genes, were fully methylated and persistently dependent on enhancer function, even after more than 30 generations in a transcriptionally active state. In plasmacytoma cells, the endogenous kappa genes were invariably hypomethylated, whereas exogenous kappa genes were hypomethylated only in cells that contain NF-kappa B and are thus permissive for kappa enhancer function. These results indicate that the linkage of hypomethylation to enhancer-dependent activation of kappa transcription occurs after the pre-B-cell stage of development. The change in methylation status, together with associated changes in chromatin structure, may suffice to eliminate or lessen the importance of the enhancer for the maintenance of the transcriptionally active state." @default.
• W1765617305 created "2016-06-24" @default.
• W1765617305 creator A5021608690 @default.
• W1765617305 creator A5044335837 @default.
• W1765617305 creator A5074237345 @default.
• W1765617305 creator A5091401702 @default.
• W1765617305 date "1988-02-01" @default.
• W1765617305 modified "2023-10-17" @default.
• W1765617305 title "The coupling between enhancer activity and hypomethylation of kappa immunoglobulin genes is developmentally regulated." @default.
• W1765617305 cites W1481046649 @default.
• W1765617305 cites W1526949464 @default.
• W1765617305 cites W1971547958 @default.
• W1765617305 cites W1973634323 @default.
• W1765617305 cites W1977209713 @default.
• W1765617305 cites W1977348907 @default.
• W1765617305 cites W1979014113 @default.
• W1765617305 cites W1980826960 @default.
• W1765617305 cites W1988178079 @default.
• W1765617305 cites W1988512414 @default.
• W1765617305 cites W1994264419 @default.
• W1765617305 cites W1994866213 @default.
• W1765617305 cites W2002981550 @default.
• W1765617305 cites W2007255991 @default.
• W1765617305 cites W2015886184 @default.
• W1765617305 cites W2016912821 @default.
• W1765617305 cites W2018775250 @default.
• W1765617305 cites W2020824064 @default.
• W1765617305 cites W2027112152 @default.
• W1765617305 cites W2041809029 @default.
• W1765617305 cites W2048574196 @default.
• W1765617305 cites W2063203673 @default.
• W1765617305 cites W2067956561 @default.
• W1765617305 cites W2068269982 @default.
• W1765617305 cites W2068817753 @default.
• W1765617305 cites W2076277128 @default.
• W1765617305 cites W2081154388 @default.
• W1765617305 cites W2084323589 @default.
• W1765617305 cites W2113394281 @default.
• W1765617305 cites W2118929543 @default.
• W1765617305 cites W2124553852 @default.
• W1765617305 cites W2133061080 @default.
• W1765617305 cites W2147693755 @default.
• W1765617305 cites W2157318791 @default.
• W1765617305 cites W2225028429 @default.
• W1765617305 cites W2311516261 @default.
• W1765617305 doi "https://doi.org/10.1128/mcb.8.2.930" @default.
• W1765617305 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/363225" @default.
• W1765617305 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3127693" @default.
• W1765617305 hasPublicationYear "1988" @default.
• W1765617305 type Work @default.
• W1765617305 sameAs 1765617305 @default.
• W1765617305 citedByCount "84" @default.
• W1765617305 countsByYear W17656173052012 @default.
• W1765617305 countsByYear W17656173052018 @default.
• W1765617305 countsByYear W17656173052019 @default.
• W1765617305 crossrefType "journal-article" @default.
• W1765617305 hasAuthorship W1765617305A5021608690 @default.
• W1765617305 hasAuthorship W1765617305A5044335837 @default.
• W1765617305 hasAuthorship W1765617305A5074237345 @default.
• W1765617305 hasAuthorship W1765617305A5091401702 @default.
• W1765617305 hasBestOaLocation W17656173052 @default.
• W1765617305 hasConcept C104317684 @default.
• W1765617305 hasConcept C111936080 @default.
• W1765617305 hasConcept C150194340 @default.
• W1765617305 hasConcept C153911025 @default.
• W1765617305 hasConcept C165864922 @default.
• W1765617305 hasConcept C190727270 @default.
• W1765617305 hasConcept C21784809 @default.
• W1765617305 hasConcept C2776985229 @default.
• W1765617305 hasConcept C54355233 @default.
• W1765617305 hasConcept C83640560 @default.
• W1765617305 hasConcept C86339819 @default.
• W1765617305 hasConcept C86803240 @default.
• W1765617305 hasConceptScore W1765617305C104317684 @default.
• W1765617305 hasConceptScore W1765617305C111936080 @default.
• W1765617305 hasConceptScore W1765617305C150194340 @default.
• W1765617305 hasConceptScore W1765617305C153911025 @default.
• W1765617305 hasConceptScore W1765617305C165864922 @default.
• W1765617305 hasConceptScore W1765617305C190727270 @default.
• W1765617305 hasConceptScore W1765617305C21784809 @default.
• W1765617305 hasConceptScore W1765617305C2776985229 @default.
• W1765617305 hasConceptScore W1765617305C54355233 @default.
• W1765617305 hasConceptScore W1765617305C83640560 @default.
• W1765617305 hasConceptScore W1765617305C86339819 @default.
• W1765617305 hasConceptScore W1765617305C86803240 @default.
• W1765617305 hasIssue "2" @default.
• W1765617305 hasLocation W17656173051 @default.
• W1765617305 hasLocation W17656173052 @default.
• W1765617305 hasLocation W17656173053 @default.
• W1765617305 hasOpenAccess W1765617305 @default.
• W1765617305 hasPrimaryLocation W17656173051 @default.
• W1765617305 hasRelatedWork W2187435303 @default.
• W1765617305 hasRelatedWork W2609050486 @default.
• W1765617305 hasRelatedWork W2779662045 @default.
• W1765617305 hasRelatedWork W2798445611 @default.
• W1765617305 hasRelatedWork W2950527165 @default.
• W1765617305 hasRelatedWork W2967307326 @default.
• W1765617305 hasRelatedWork W4205710992 @default.

• next