FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1765804919> ?p ?o ?g. }

• W1765804919 endingPage "4464" @default.
• W1765804919 startingPage "4455" @default.
• W1765804919 abstract "Separate genetic elements (V, D, and J) encode the variable regions of lymphocyte antigen receptors. During early lymphocyte differentiation, these elements rearrange to form contiguous coding segments (VJ and VDJ) for a diverse array of variable regions. Rearrangement is mediated by a recombinase that recognizes short DNA sequences (signals) flanking V, D, and J elements. Signals flank both the 5' and 3' sides of each D element, thereby allowing assembly of a functional VDJ gene. However, in rearrangements involving the D delta 2 and J delta 1 elements of the mouse T-cell receptor delta (TCR delta) locus, we unexpectedly found that the D delta 2 element and a portion of its 5' signal are often deleted. Approximately 50% of recovered D delta 2 to J delta 1 rearrangements from thymocytes of adult wild-type mice showed such deletions. An additional 20% of the rearrangements contained standard D delta 2-J delta 1 coding junctions but showed some loss of nucleotides from the 5' D delta 2 signal. This loss was clearly associated with another event involving a site-specific cleavage at the 5' signal/coding border of D delta 2 and rejoining of the modified signal and coding ends. The abnormal loss of D delta 2 and a portion of the 5' D delta 2 signal was infrequently observed in D delta 2-to-J delta 1 rearrangements recovered from neonatal mice. The possible basis and significance of this age-dependent phenomenon are discussed." @default.
• W1765804919 created "2016-06-24" @default.
• W1765804919 creator A5038396889 @default.
• W1765804919 creator A5043734620 @default.
• W1765804919 date "1994-07-01" @default.
• W1765804919 modified "2023-09-27" @default.
• W1765804919 title "Abnormal deletions in the T-cell receptor delta locus of mouse thymocytes" @default.
• W1765804919 cites W112919321 @default.
• W1765804919 cites W138159952 @default.
• W1765804919 cites W1488045575 @default.
• W1765804919 cites W1520821970 @default.
• W1765804919 cites W1680049018 @default.
• W1765804919 cites W1836532605 @default.
• W1765804919 cites W1911716715 @default.
• W1765804919 cites W1964625649 @default.
• W1765804919 cites W1966427800 @default.
• W1765804919 cites W1969733242 @default.
• W1765804919 cites W1978791876 @default.
• W1765804919 cites W1979836429 @default.
• W1765804919 cites W1983302719 @default.
• W1765804919 cites W1983988848 @default.
• W1765804919 cites W1991756452 @default.
• W1765804919 cites W1994911637 @default.
• W1765804919 cites W1996642422 @default.
• W1765804919 cites W1997056099 @default.
• W1765804919 cites W2000110243 @default.
• W1765804919 cites W2009632063 @default.
• W1765804919 cites W2010776654 @default.
• W1765804919 cites W2012621186 @default.
• W1765804919 cites W2013835825 @default.
• W1765804919 cites W2022015009 @default.
• W1765804919 cites W2023161185 @default.
• W1765804919 cites W2024214216 @default.
• W1765804919 cites W2033938686 @default.
• W1765804919 cites W2037517612 @default.
• W1765804919 cites W2039183914 @default.
• W1765804919 cites W2045417932 @default.
• W1765804919 cites W2048574196 @default.
• W1765804919 cites W2048976298 @default.
• W1765804919 cites W2064631075 @default.
• W1765804919 cites W2066913325 @default.
• W1765804919 cites W2067133629 @default.
• W1765804919 cites W2081820824 @default.
• W1765804919 cites W2085115144 @default.
• W1765804919 cites W2089155355 @default.
• W1765804919 cites W2089921678 @default.
• W1765804919 cites W2091127678 @default.
• W1765804919 cites W2092450783 @default.
• W1765804919 cites W2092700608 @default.
• W1765804919 cites W2094325198 @default.
• W1765804919 cites W2107868425 @default.
• W1765804919 cites W2115494245 @default.
• W1765804919 cites W2122385641 @default.
• W1765804919 cites W2122688151 @default.
• W1765804919 cites W2125622789 @default.
• W1765804919 cites W2128205954 @default.
• W1765804919 cites W2139968053 @default.
• W1765804919 cites W2319164130 @default.
• W1765804919 cites W305844696 @default.
• W1765804919 cites W69213376 @default.
• W1765804919 cites W1974596630 @default.
• W1765804919 doi "https://doi.org/10.1128/mcb.14.7.4455-4464.1994" @default.
• W1765804919 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/358817" @default.
• W1765804919 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8007952" @default.
• W1765804919 hasPublicationYear "1994" @default.
• W1765804919 type Work @default.
• W1765804919 sameAs 1765804919 @default.
• W1765804919 citedByCount "3" @default.
• W1765804919 countsByYear W17658049192013 @default.
• W1765804919 crossrefType "journal-article" @default.
• W1765804919 hasAuthorship W1765804919A5038396889 @default.
• W1765804919 hasAuthorship W1765804919A5043734620 @default.
• W1765804919 hasConcept C102414288 @default.
• W1765804919 hasConcept C104317684 @default.
• W1765804919 hasConcept C121332964 @default.
• W1765804919 hasConcept C1276947 @default.
• W1765804919 hasConcept C153911025 @default.
• W1765804919 hasConcept C156695909 @default.
• W1765804919 hasConcept C157402786 @default.
• W1765804919 hasConcept C19317047 @default.
• W1765804919 hasConcept C2776090121 @default.
• W1765804919 hasConcept C2780254951 @default.
• W1765804919 hasConcept C2992511266 @default.
• W1765804919 hasConcept C5072461 @default.
• W1765804919 hasConcept C54355233 @default.
• W1765804919 hasConcept C84597430 @default.
• W1765804919 hasConcept C86803240 @default.
• W1765804919 hasConcept C8891405 @default.
• W1765804919 hasConcept C91779695 @default.
• W1765804919 hasConceptScore W1765804919C102414288 @default.
• W1765804919 hasConceptScore W1765804919C104317684 @default.
• W1765804919 hasConceptScore W1765804919C121332964 @default.
• W1765804919 hasConceptScore W1765804919C1276947 @default.
• W1765804919 hasConceptScore W1765804919C153911025 @default.
• W1765804919 hasConceptScore W1765804919C156695909 @default.
• W1765804919 hasConceptScore W1765804919C157402786 @default.
• W1765804919 hasConceptScore W1765804919C19317047 @default.
• W1765804919 hasConceptScore W1765804919C2776090121 @default.

• next