Matches in SemOpenAlex for { <https://semopenalex.org/work/W1766454893> ?p ?o ?g. }
- W1766454893 endingPage "42" @default.
- W1766454893 startingPage "37" @default.
- W1766454893 abstract "Newcastle disease virus (NDV) is the causative agent of Newcastle disease, which is characterized by inflammatory pathological changes in the organs of chickens. The inflammatory response to this disease has not been well characterized. Previous reports showed that the sphingosine-1-phosphate-1 receptor (S1PR1), a G protein-coupled receptor, is important to the activation of inflammatory responses. To understand better the viral pathogenesis and host inflammatory response, we analyzed S1PR1 expression during NDV infection. We observed a direct correlation between chicken embryo fibroblast (CEF) cellular inflammatory responses and S1PR1 expression. Virulent NDV-infected CEF cells also had elevated levels of pro-inflammatory cytokines (IL-1β, IL-6 and IL-18). When S1PR1 was inhibited by using the specific antagonist W146, pro-inflammatory cytokine production declined. Overexpression of S1PR1 resulted in increased virus-induced IL-1β production. S1PR1 expression levels did not impact significantly NDV replication. These findings highlight the important role of S1PR1 in inflammatory responses in NDV infection." @default.
- W1766454893 created "2016-06-24" @default.
- W1766454893 creator A5003417990 @default.
- W1766454893 creator A5013446626 @default.
- W1766454893 creator A5028376798 @default.
- W1766454893 creator A5042146073 @default.
- W1766454893 creator A5053792824 @default.
- W1766454893 creator A5072187720 @default.
- W1766454893 creator A5073353299 @default.
- W1766454893 creator A5082902882 @default.
- W1766454893 creator A5085205645 @default.
- W1766454893 date "2016-01-01" @default.
- W1766454893 modified "2023-10-04" @default.
- W1766454893 title "S1PR1 expression correlates with inflammatory responses to Newcastle disease virus infection" @default.
- W1766454893 cites W1577104198 @default.
- W1766454893 cites W1617476374 @default.
- W1766454893 cites W1969788014 @default.
- W1766454893 cites W1975147385 @default.
- W1766454893 cites W1975461687 @default.
- W1766454893 cites W1986162557 @default.
- W1766454893 cites W1992974015 @default.
- W1766454893 cites W2004351923 @default.
- W1766454893 cites W2007737411 @default.
- W1766454893 cites W2014526282 @default.
- W1766454893 cites W2024921751 @default.
- W1766454893 cites W2029440821 @default.
- W1766454893 cites W2031051020 @default.
- W1766454893 cites W2035208392 @default.
- W1766454893 cites W2036233373 @default.
- W1766454893 cites W2040324632 @default.
- W1766454893 cites W2047471583 @default.
- W1766454893 cites W2061736146 @default.
- W1766454893 cites W2062460198 @default.
- W1766454893 cites W2069114926 @default.
- W1766454893 cites W2072142282 @default.
- W1766454893 cites W2073447768 @default.
- W1766454893 cites W2076013621 @default.
- W1766454893 cites W2076073786 @default.
- W1766454893 cites W2107277218 @default.
- W1766454893 cites W2138897186 @default.
- W1766454893 cites W2142923098 @default.
- W1766454893 cites W2165275387 @default.
- W1766454893 cites W2166036680 @default.
- W1766454893 cites W2169580116 @default.
- W1766454893 cites W2312502013 @default.
- W1766454893 doi "https://doi.org/10.1016/j.meegid.2015.10.021" @default.
- W1766454893 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26597451" @default.
- W1766454893 hasPublicationYear "2016" @default.
- W1766454893 type Work @default.
- W1766454893 sameAs 1766454893 @default.
- W1766454893 citedByCount "18" @default.
- W1766454893 countsByYear W17664548932016 @default.
- W1766454893 countsByYear W17664548932017 @default.
- W1766454893 countsByYear W17664548932018 @default.
- W1766454893 countsByYear W17664548932019 @default.
- W1766454893 countsByYear W17664548932020 @default.
- W1766454893 countsByYear W17664548932021 @default.
- W1766454893 countsByYear W17664548932022 @default.
- W1766454893 countsByYear W17664548932023 @default.
- W1766454893 crossrefType "journal-article" @default.
- W1766454893 hasAuthorship W1766454893A5003417990 @default.
- W1766454893 hasAuthorship W1766454893A5013446626 @default.
- W1766454893 hasAuthorship W1766454893A5028376798 @default.
- W1766454893 hasAuthorship W1766454893A5042146073 @default.
- W1766454893 hasAuthorship W1766454893A5053792824 @default.
- W1766454893 hasAuthorship W1766454893A5072187720 @default.
- W1766454893 hasAuthorship W1766454893A5073353299 @default.
- W1766454893 hasAuthorship W1766454893A5082902882 @default.
- W1766454893 hasAuthorship W1766454893A5085205645 @default.
- W1766454893 hasConcept C140800825 @default.
- W1766454893 hasConcept C146285616 @default.
- W1766454893 hasConcept C159047783 @default.
- W1766454893 hasConcept C167734588 @default.
- W1766454893 hasConcept C203014093 @default.
- W1766454893 hasConcept C2522874641 @default.
- W1766454893 hasConcept C2776914184 @default.
- W1766454893 hasConcept C2777025900 @default.
- W1766454893 hasConcept C2778116459 @default.
- W1766454893 hasConcept C2778690821 @default.
- W1766454893 hasConcept C2780942790 @default.
- W1766454893 hasConcept C502942594 @default.
- W1766454893 hasConcept C86803240 @default.
- W1766454893 hasConceptScore W1766454893C140800825 @default.
- W1766454893 hasConceptScore W1766454893C146285616 @default.
- W1766454893 hasConceptScore W1766454893C159047783 @default.
- W1766454893 hasConceptScore W1766454893C167734588 @default.
- W1766454893 hasConceptScore W1766454893C203014093 @default.
- W1766454893 hasConceptScore W1766454893C2522874641 @default.
- W1766454893 hasConceptScore W1766454893C2776914184 @default.
- W1766454893 hasConceptScore W1766454893C2777025900 @default.
- W1766454893 hasConceptScore W1766454893C2778116459 @default.
- W1766454893 hasConceptScore W1766454893C2778690821 @default.
- W1766454893 hasConceptScore W1766454893C2780942790 @default.
- W1766454893 hasConceptScore W1766454893C502942594 @default.
- W1766454893 hasConceptScore W1766454893C86803240 @default.
- W1766454893 hasFunder F4320321001 @default.
- W1766454893 hasFunder F4320336024 @default.
- W1766454893 hasLocation W17664548931 @default.