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- W176660125 abstract "The application of living bacteria as probiotics in food or food supplements requires a careful safety assessment. This review summarizes key issues concerning the safety aspects of bacteria added to particular products marketed for improvement of general health or treatment of (post)infectious symptoms. The bacteria used in such products should be completely safe; however, it can be challenging to provide evidence for absence of all virulence properties. In some cases, virulence factors have been detected in probiotic bacterial strains, and the implications of these traits for safety assessments are discussed. Horizontal gene transfer can result in acquisition of virulence genes or antimicrobial resistance in probiotic bacteria. Antimicrobial resistance in these bacteria can possibly aid the spread of undesired resistance in intestinal bacterial populations. The relative risk of such gene transfers is considered. The generation of complete bacterial genome sequences can both resolve and create safety issues. Current practices of safety assessment procedures in the United States and the European Union are briefly reviewed and a future outlook is provided." @default.
- W176660125 created "2016-06-24" @default.
- W176660125 creator A5040865897 @default.
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- W176660125 date "2008-08-01" @default.
- W176660125 modified "2023-10-16" @default.
- W176660125 title "Safety Aspects and Implications of Regulation of Probiotic Bacteria in Food and Food Supplements" @default.
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- W176660125 doi "https://doi.org/10.4315/0362-028x-71.8.1734" @default.
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