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• W17666543 abstract "This chapter reviews the methods used to investigate clonality, and discusses the results of such investigations. As carcinogenesis is a multistep process in the course of which cell division occurs, there are three possibilities to consider. First, the founder cell of a neoplastic clone may be defined as an initially normal cell which undergoes one or more of the steps on the way to transformation before it divide, and some of whose descendants become fully transformed. Second, the founder cell may be defined as a cell whose immediate parent had undergone all except the last of the steps on the way to transformation, and which undergoes the last step before it divides. Third, when a stable marker appears for the first time in a cell that lies somewhere between these extremes, it may be convenient to choose this cell as a founder. The markers that have been used to study the clonality of human and/or animal tumors may be classified as : (1) X-linked markers: alloenzymes and restriction fragment length polymorphisms; (2) karyotypic and other chromosomal markers; (3) immunoglobulins (Ig) and Ig-gene rearrangements; (4) cell surface markers other than immunoglobulin; and (5) markers in natural or artificially produced chimeras. This chapter discusses how these markers have been used to try to discriminate between monoclonal and pleoclonal tumors." @default.
• W17666543 created "2016-06-24" @default.
• W17666543 creator A5058598921 @default.
• W17666543 date "1988-01-01" @default.
• W17666543 modified "2023-09-23" @default.
• W17666543 title "Tumor Clonality And Its Biological Significance" @default.
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• W17666543 doi "https://doi.org/10.1016/s0065-230x(08)60438-8" @default.
• W17666543 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3287843" @default.
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