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• W1766879868 abstract "Using nanoparticle delivery for anticancer therapy is a potential new drug modality. We developed a novel gelatinase-stimuli nanoparticle. In this study, we studied the antitumor and antimetastasis effect of pemetrexed-loaded targeted nanoparticles and evaluated the correlation between E-cadherin expression and lung metastasis in subcutaneous xenograft model. Compared with free pemetrexed, pemetrexed-loaded targeted nanoparticles exhibited the best antitumor and antimetastasis efficacy among the four therapeutic groups. The study also indicated that there was an inverse correlation between lung metastasis and E-cadherin expression. These results showed pemetrexed-loaded targeted nanoparticles may be a potent drug for tumor therapy and our preclinical data could provide new direction for clinical therapy of malignant melanoma." @default.
• W1766879868 created "2016-06-24" @default.
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• W1766879868 date "2015-05-22" @default.
• W1766879868 modified "2023-09-28" @default.
• W1766879868 title "Antitumor and antimetastatic effects of pemetrexed-loaded targeted nanoparticles in B₁₆ bearing mice" @default.
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• W1766879868 doi "https://doi.org/10.3109/10717544.2015.1033794" @default.
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