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- W176717546 abstract "Porphyrins and bile pigment are examples of tetrapyrrolic pigments and this group of pigments are the most widely occurring coloured materials in nature. Porphyrin structures are based on the porphin nucleus with side chains substituted on the various peripheral positions. The basic structures of the porphyrins related to haem biosynthesis and of haematoporphyrin (Hp) and related porphyrins which are of importance in cancer photo-chemotherapy are shown in Figure 1. It was first demonstrated by Meyer-Betz in 1913 that porphyrins are related to photodynamic activity in man and it is now established that the photosensitivity associated with various porphyric diseases is due to the presence of excess porphyrin in the skin. The porphyrins which cause porphyria arise by a disfunction of haem biosynthesis and vary in structure depending on the particular step in the biosynthetic pathway at which the enzymic disfunction occurs. The so-called ‘Hp Derivative’ (HpD) is currently of interest in the photochemotherapy of some tumours. Current views of the nature of the active component of HpD is that it consists of a substantial number of Hp molecules linked via ether bridges with the overall structure that of a folded molecule. It is presumed that such a macromolecule can transfer one Hp or possibly one hydroxyethylvinyldeuteroporphyrin (HVD) entity at a time on interaction with a tumour cell. It is also possible that Hp and HVD are in equilibrium with protoporphyrin (pp) and even deuteroporphyrin (dp)1 in the tumour." @default.
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- W176717546 date "1985-01-01" @default.
- W176717546 modified "2023-09-26" @default.
- W176717546 title "Photochemistry of Porphyrins and Bile Pigments in Homogeneous Solution" @default.
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- W176717546 doi "https://doi.org/10.1007/978-1-4684-1224-6_17" @default.
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