Matches in SemOpenAlex for { <https://semopenalex.org/work/W1768118032> ?p ?o ?g. }
Showing items 1 to 69 of
69
with 100 items per page.
- W1768118032 abstract "Oxygen radicals and related “reactive oxygen species” (ROS) are fundamental to human life; they help drive evolution and the damage that they can do (“oxidative damage”) is involved in most, if not all, human diseases, especially neurodegenerative diseases and stroke, and in ageing itself. Nevertheless, ROS have beneficial effects in killing invading organisms and facilitating signal transduction, especially in coordinating the inflammatory response. In establishing the role of ROS in disease, frequent use is made of animal models and of cell culture. Yet animal models have rarely been predictive of the outcome of clinical trials of antioxidant drugs in human disease, especially the neurodegenerative diseases and stroke. Reasons for this will be explored, but our studies on human stroke patients may illustrate one reason why. Even more questionable is cell culture. Cell culture is an example of hyperoxia-induced oxidative stress and how cells adapt to it, mutating rapidly and changing their metabolism. Culture media often interact in complex ways with added “antioxidants”, sometimes catalyzing their oxidation to H 2 O 2 and other cytotoxic species. Hence one must take great care to avoid artefacts when interpreting the effects of added antioxidants or other compounds upon cells in culture. The apparent ability of ascorbate and polyphenols to kill cancer cells is one such artefact." @default.
- W1768118032 created "2016-06-24" @default.
- W1768118032 creator A5053726981 @default.
- W1768118032 date "2015-09-01" @default.
- W1768118032 modified "2023-09-27" @default.
- W1768118032 title "SNFS Advances in Nutrition Lecture - Sponsored by SNFS" @default.
- W1768118032 doi "https://doi.org/10.1016/j.freeradbiomed.2015.07.026" @default.
- W1768118032 hasPublicationYear "2015" @default.
- W1768118032 type Work @default.
- W1768118032 sameAs 1768118032 @default.
- W1768118032 citedByCount "1" @default.
- W1768118032 countsByYear W17681180322019 @default.
- W1768118032 crossrefType "journal-article" @default.
- W1768118032 hasAuthorship W1768118032A5053726981 @default.
- W1768118032 hasConcept C142724271 @default.
- W1768118032 hasConcept C169760540 @default.
- W1768118032 hasConcept C2776151105 @default.
- W1768118032 hasConcept C2778004101 @default.
- W1768118032 hasConcept C2779134260 @default.
- W1768118032 hasConcept C2988867146 @default.
- W1768118032 hasConcept C48349386 @default.
- W1768118032 hasConcept C54355233 @default.
- W1768118032 hasConcept C55493867 @default.
- W1768118032 hasConcept C60644358 @default.
- W1768118032 hasConcept C71924100 @default.
- W1768118032 hasConcept C81885089 @default.
- W1768118032 hasConcept C86803240 @default.
- W1768118032 hasConcept C95444343 @default.
- W1768118032 hasConceptScore W1768118032C142724271 @default.
- W1768118032 hasConceptScore W1768118032C169760540 @default.
- W1768118032 hasConceptScore W1768118032C2776151105 @default.
- W1768118032 hasConceptScore W1768118032C2778004101 @default.
- W1768118032 hasConceptScore W1768118032C2779134260 @default.
- W1768118032 hasConceptScore W1768118032C2988867146 @default.
- W1768118032 hasConceptScore W1768118032C48349386 @default.
- W1768118032 hasConceptScore W1768118032C54355233 @default.
- W1768118032 hasConceptScore W1768118032C55493867 @default.
- W1768118032 hasConceptScore W1768118032C60644358 @default.
- W1768118032 hasConceptScore W1768118032C71924100 @default.
- W1768118032 hasConceptScore W1768118032C81885089 @default.
- W1768118032 hasConceptScore W1768118032C86803240 @default.
- W1768118032 hasConceptScore W1768118032C95444343 @default.
- W1768118032 hasLocation W17681180321 @default.
- W1768118032 hasOpenAccess W1768118032 @default.
- W1768118032 hasPrimaryLocation W17681180321 @default.
- W1768118032 hasRelatedWork W1237385790 @default.
- W1768118032 hasRelatedWork W1990813136 @default.
- W1768118032 hasRelatedWork W1999891390 @default.
- W1768118032 hasRelatedWork W2021109031 @default.
- W1768118032 hasRelatedWork W2023374241 @default.
- W1768118032 hasRelatedWork W2027043265 @default.
- W1768118032 hasRelatedWork W2039799010 @default.
- W1768118032 hasRelatedWork W2064853445 @default.
- W1768118032 hasRelatedWork W2071830711 @default.
- W1768118032 hasRelatedWork W2081088951 @default.
- W1768118032 hasRelatedWork W2289192105 @default.
- W1768118032 hasRelatedWork W2612686895 @default.
- W1768118032 hasRelatedWork W2740695644 @default.
- W1768118032 hasRelatedWork W274273259 @default.
- W1768118032 hasRelatedWork W2969778414 @default.
- W1768118032 hasRelatedWork W3041267898 @default.
- W1768118032 hasRelatedWork W3047716900 @default.
- W1768118032 hasRelatedWork W3114674668 @default.
- W1768118032 hasRelatedWork W3126681144 @default.
- W1768118032 hasRelatedWork W3190048637 @default.
- W1768118032 isParatext "false" @default.
- W1768118032 isRetracted "false" @default.
- W1768118032 magId "1768118032" @default.
- W1768118032 workType "article" @default.