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- W1768164894 abstract "This chapter discusses the preparation and applications of multivalent antibodies with dual specificity. Antibody molecules of dual specificity can be obtained by combining univalent Fab' fragments from antibodies of different specificity. As compared with the hybrid antibody prepared by recombination of Fab' fragments, the main advantage of the hybrid SpA-antibody complex is its simplicity of preparation, purity, and multivalency. By its multivalency (four combining sites per antibody partner of the complex), the hybrid antibody complexes have an increased functional affinity for the corresponding antigens, as reported for SpA-antibody complexes with a single specificity. Hence, the gain in avidity allows the hybrid SpA-antibody complexes to draw together not only soluble antigens but also particulate ones (for example, cells, bacteria, viruses). Such multivalent hybrid SpA-antibody complexes are useful tools for the study of cell-to-cell interaction and location of cell-surface antigens." @default.
- W1768164894 created "2016-06-24" @default.
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- W1768164894 date "1983-01-01" @default.
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- W1768164894 title "[40] Preparation and applications of multivalent antibodies with dual specificity" @default.
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- W1768164894 doi "https://doi.org/10.1016/0076-6879(83)92043-8" @default.
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