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- W176817008 abstract "As indicated previously, pig organs appear to be the most suitable to use for vascularized transplants for humans [1, 2]. The social need for this has been covered elsewhere in this volume, as has the major problem - hyperacute antibody mediated rejection (HAR). It has been known for many years that all humans have naturally occurring cytotoxic and hemagglutinating antibodies reacting with pig antigens [3], and it is clear that these antibodies would cause, within minutes, the rejection of vascularized pig tissues such as heart, liver, kidney, pancreas, or lung after transplantation to humans. Examples of HAR in pig to human transplantation, particularly for kidney and liver, are described elsewhere in this volume. The interacting components in HAR are: (a) antigen, (b) IgG and IgM antibodies, and (c) complement (C). There is little doubt that if there were neither antigen (the subject of this chapter), nor antibody or C [4, 5], then HAR would not occur, the graft would survive for days (at least) and other mechanisms of rejection would then come into play. The modes of removal of antibodies and/or C are described elsewhere; here we will discuss modifying the antigens to prevent HAR; we do not discuss antigens involved in the later phases of rejection which could involve both antibody and cellular mechanisms as the primary components." @default.
- W176817008 created "2016-06-24" @default.
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- W176817008 date "1997-01-01" @default.
- W176817008 modified "2023-09-26" @default.
- W176817008 title "Overcoming the Anti-Galα(1–3)Gal Reaction To Avoid Hyperacute Rejection: Molecular Genetic Approaches" @default.
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- W176817008 doi "https://doi.org/10.1007/978-3-642-60572-7_50" @default.
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