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• W1768175145 abstract "Abstract Motivation: Effective computational methods for peptide-protein binding prediction can greatly help clinical peptide vaccine search and design. However, previous computational methods fail to capture key nonlinear high-order dependencies between different amino acid positions. As a result, they often produce low-quality rankings of strong binding peptides. To solve this problem, we propose nonlinear high-order machine learning methods including high-order neural networks (HONNs) with possible deep extensions and high-order kernel support vector machines to predict major histocompatibility complex-peptide binding. Results: The proposed high-order methods improve quality of binding predictions over other prediction methods. With the proposed methods, a significant gain of up to 25–40% is observed on the benchmark and reference peptide datasets and tasks. In addition, for the first time, our experiments show that pre-training with high-order semi-restricted Boltzmann machines significantly improves the performance of feed-forward HONNs. Moreover, our experiments show that the proposed shallow HONN outperform the popular pre-trained deep neural network on most tasks, which demonstrates the effectiveness of modelling high-order feature interactions for predicting major histocompatibility complex-peptide binding. Availability and implementation: There is no associated distributable software. Contact: renqiang@nec-labs.com or mark.gerstein@yale.edu Supplementary information: Supplementary data are available at Bioinformatics online." @default.
• W1768175145 created "2016-06-24" @default.
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• W1768175145 date "2015-07-23" @default.
• W1768175145 modified "2023-10-10" @default.
• W1768175145 title "High-order neural networks and kernel methods for peptide-MHC binding prediction" @default.
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• W1768175145 doi "https://doi.org/10.1093/bioinformatics/btv371" @default.
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