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• W176825721 abstract "A mild reduction in mitochondrial respiration extends the life span of many species, including C. elegans. We recently showed that hypoxia-inducible factor 1 (HIF-1) is required for the acquisition of a long life span by mutants with reduced respiration in C. elegans. We suggested that increased levels of reactive oxygen species (ROS) produced in the respiration mutants increase HIF-1 activity and lead to this longevity. In this research perspective, we discuss our findings and recent advances regarding the roles of ROS and HIF-1 in aging, focusing on the longevity caused by reduced respiration." @default.
• W176825721 created "2016-06-24" @default.
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• W176825721 date "2011-03-06" @default.
• W176825721 modified "2023-09-23" @default.
• W176825721 title "Regulation of life span by mitochondrial respiration: the HIF-1 and ROS connection" @default.
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• W176825721 doi "https://doi.org/10.18632/aging.100292" @default.
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