Matches in SemOpenAlex for { <https://semopenalex.org/work/W1768551428> ?p ?o ?g. }
- W1768551428 abstract "In chronic myeloid leukaemia (CML), as with other tumour types, mutations of the p53 gene are associated with disease progression. Changes in regional methylation of DNA with CML tumour development have also been demonstrated. Methylation is one mechanism by which gene expression is controlled and the CpG sites, which are the targets of DNA methylation, are also the sites of a number of the mutations found in the p53 gene. Cells harbouring mutant p53 have been shown to accumulate further genomic and genetic aberrations and methylation which alters the conformation of DNA is also believed to play a role in genomic stability. There appears to be an interplay between p53 deregulation and changing methylation patterns with the progression of CML. The cause and effect of changes in both of these critical gene regulating, DNA repair and genomic stability factors and their deviation during the progression of CML will be discussed." @default.
- W1768551428 created "2016-06-24" @default.
- W1768551428 creator A5057414314 @default.
- W1768551428 creator A5070520397 @default.
- W1768551428 date "1997-01-01" @default.
- W1768551428 modified "2023-09-23" @default.
- W1768551428 title "p53 Mutations, Methylation and Genomic Instability in the Progression of Chronic Myeloid Leukaemia" @default.
- W1768551428 cites W115186932 @default.
- W1768551428 cites W1602222199 @default.
- W1768551428 cites W1760723619 @default.
- W1768551428 cites W1878410949 @default.
- W1768551428 cites W1965874480 @default.
- W1768551428 cites W1967161001 @default.
- W1768551428 cites W1968374691 @default.
- W1768551428 cites W1968426702 @default.
- W1768551428 cites W1974747095 @default.
- W1768551428 cites W1980847511 @default.
- W1768551428 cites W1983200031 @default.
- W1768551428 cites W1983543728 @default.
- W1768551428 cites W1983916386 @default.
- W1768551428 cites W1985014165 @default.
- W1768551428 cites W1985524321 @default.
- W1768551428 cites W1998191493 @default.
- W1768551428 cites W1998328861 @default.
- W1768551428 cites W1998593414 @default.
- W1768551428 cites W1999275729 @default.
- W1768551428 cites W2001258296 @default.
- W1768551428 cites W2002696114 @default.
- W1768551428 cites W2002933072 @default.
- W1768551428 cites W2011727075 @default.
- W1768551428 cites W2012053348 @default.
- W1768551428 cites W2013143444 @default.
- W1768551428 cites W2014798701 @default.
- W1768551428 cites W2018385269 @default.
- W1768551428 cites W2019160131 @default.
- W1768551428 cites W2021495157 @default.
- W1768551428 cites W2027591919 @default.
- W1768551428 cites W2028673078 @default.
- W1768551428 cites W2032972450 @default.
- W1768551428 cites W2033786191 @default.
- W1768551428 cites W2033977832 @default.
- W1768551428 cites W2034200430 @default.
- W1768551428 cites W2042883018 @default.
- W1768551428 cites W2043322530 @default.
- W1768551428 cites W2047718954 @default.
- W1768551428 cites W2049527615 @default.
- W1768551428 cites W2054549064 @default.
- W1768551428 cites W2070100030 @default.
- W1768551428 cites W2071808385 @default.
- W1768551428 cites W2077858999 @default.
- W1768551428 cites W2079192620 @default.
- W1768551428 cites W2079384901 @default.
- W1768551428 cites W2082668438 @default.
- W1768551428 cites W2084118479 @default.
- W1768551428 cites W2085193833 @default.
- W1768551428 cites W2085578219 @default.
- W1768551428 cites W2091070405 @default.
- W1768551428 cites W2091349362 @default.
- W1768551428 cites W2095256418 @default.
- W1768551428 cites W2100191628 @default.
- W1768551428 cites W2102149360 @default.
- W1768551428 cites W2108172661 @default.
- W1768551428 cites W2109150993 @default.
- W1768551428 cites W2125079668 @default.
- W1768551428 cites W2125300115 @default.
- W1768551428 cites W2153715492 @default.
- W1768551428 cites W2155009866 @default.
- W1768551428 cites W2157531467 @default.
- W1768551428 cites W2162258100 @default.
- W1768551428 cites W2166203203 @default.
- W1768551428 cites W2169761030 @default.
- W1768551428 cites W2395538984 @default.
- W1768551428 cites W2396892382 @default.
- W1768551428 cites W2403235282 @default.
- W1768551428 cites W2404887513 @default.
- W1768551428 cites W2415003134 @default.
- W1768551428 cites W2423152122 @default.
- W1768551428 cites W4235262218 @default.
- W1768551428 cites W4237139115 @default.
- W1768551428 cites W4237666438 @default.
- W1768551428 cites W4242822964 @default.
- W1768551428 doi "https://doi.org/10.3109/10428199709051771" @default.
- W1768551428 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9322884" @default.
- W1768551428 hasPublicationYear "1997" @default.
- W1768551428 type Work @default.
- W1768551428 sameAs 1768551428 @default.
- W1768551428 citedByCount "34" @default.
- W1768551428 countsByYear W17685514282013 @default.
- W1768551428 countsByYear W17685514282014 @default.
- W1768551428 countsByYear W17685514282015 @default.
- W1768551428 countsByYear W17685514282016 @default.
- W1768551428 countsByYear W17685514282018 @default.
- W1768551428 countsByYear W17685514282020 @default.
- W1768551428 countsByYear W17685514282021 @default.
- W1768551428 crossrefType "journal-article" @default.
- W1768551428 hasAuthorship W1768551428A5057414314 @default.
- W1768551428 hasAuthorship W1768551428A5070520397 @default.
- W1768551428 hasConcept C104317684 @default.
- W1768551428 hasConcept C140173407 @default.
- W1768551428 hasConcept C143065580 @default.