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- W1768579721 abstract "Background: The cardiovascular disturbances are the important pathways in the development of perinatal asphyxia. Study of genetic markers associated with the development of severe asphyxia in newborns is of great practical importance to develop preventive measures and child health in the future. The aim of this study was to evaluate the influence of the (I/D) gene polymorphism on the development of severe perinatal asphyxia. Methods: We conducted a case-control study of 80 cases of severe perinatal asphyxia and 110 control group. For the genotyping was used polymerase chain reaction (PCR) with further restriction fragments length polymorphism analyses. The differences in comparative groups were assessed by the Pearson chi-square test analyses and Odds Ratio determination. Results: The incidence of the homozygous DD alleles in the neonates with severe perinatal asphyxia was 33 (41,25%), of the heterozygous ID alleles 37 (46,25%), of the homozygous II alleles 10 (12,50%). The neonates of control group had following alleles: DD - 15 (13,64%), ID- 44 (40,00%), II -51 (46,36%). Conclusion: DD gene polymorphism of the neonates is a risk factor for the development of perinatal asphyxia. We suggest using these genetic markers in prognosis of severe perinatal asphyxia in the neonates." @default.
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- W1768579721 date "2011-09-01" @default.
- W1768579721 modified "2023-09-24" @default.
- W1768579721 title "The influence of angiotensin-converting enzyme (ACE) genotype on the development of severe perinatal asphyxia in the neonates" @default.
- W1768579721 hasPublicationYear "2011" @default.
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