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- W1768908853 abstract "Non-invasive continuous positive airway pressure (CPAP) has been proved to rapidly improve oxygenation in moderate hypoxemic acute respiratory failure (ARF) due to pneumonia. No prospective randomized studies evaluated the role of CPAP in improving outcomes of patients with pneumonia. The aim of the study was to compare CPAP vs.Venturi Mask oxygen therapy (VM) in terms of criteria for endotracheal intubation (ETI) during pneumonia. This was a multicenter, prospective, randomized, controlled trial enrolling patients with severe hypoxemic ARF due to pneumonia (defined as PaO2/FiO2 ratio≤250 in VM with FiO2≥0.5 and respiratory rate≥30 breaths/min or respiratory distress) admitted to four Italian emergency departments from Feb. 2010 to Jan. 2013. Patients were randomized to receive CPAP delivered by a helmet or oxygen delivered with a VM. Criteria for ETI included ≥1 of major criteria (respiratory arrest, respiratory pauses with unconsciousness, severe hemodynamic instability, need of sedation) or ≥2 of minor criteria maintained for at least 1 hour (reduction of ≥30% of basal PaO2/FiO2 ratio, increasing of 20% of PaCO2 if basal PaCO2 was≥40 mmHg, worsening of alertness, respiratory distress, SpO2 Non-invasive CPAP delivered by a helmet reduces the risk of meeting ETI criteria in comparison to oxygen therapy in patients with severe ARF due to pneumonia." @default.
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- W1768908853 date "2013-09-01" @default.
- W1768908853 modified "2023-09-28" @default.
- W1768908853 title "Non-invasive continuous positive airway pressure versus oxygen venturi in severe acute respiratory failure due to pneumonia: A randomized controlled trial" @default.
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