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• W17689944 startingPage "199" @default.
• W17689944 abstract "Sepsis syndrome is a constellation of clinical findings that includes three major features: a site of inflammation; presence of abnormal vital signs (altered temperature, tachycardia and an increased minute ventilation); and at least one organ system failure (renal, hepatic, circulatory, haematological or neurological). More than 400 000 cases of sepsis syndrome occur in the USA alone each year, resulting in the expenditure of 5-10 billion dollars annually (1). The case fatality rate ranges from 20% to 60% (2,3). Importantly, one-half of afflicted patients have no demonstrable infection (4) and numerous non-infectious disorders mimic sepsis syndrome. These two facts have prompted investigators to propose renaming “sepsis syndrome” the “systemic inflammatory response syndrome” (SIRS), emphasizing that infection is not essential and that the host response is the critical determinant of severity. Although SIRS may result from non-infectious causes or viral, fungal or Gram-positive infections, Gram-negative bacteria constitute the single largest group of microbiological isolates, accounting for about one–third of all cases (1, 4-6)." @default.
• W17689944 created "2016-06-24" @default.
• W17689944 creator A5061640269 @default.
• W17689944 creator A5077888222 @default.
• W17689944 date "1995-01-01" @default.
• W17689944 modified "2023-09-26" @default.
• W17689944 title "Cytokine Antibodies and Antagonists in the Treatment of Sepsis" @default.
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