FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1769192511> ?p ?o ?g. }

• W1769192511 endingPage "5651" @default.
• W1769192511 startingPage "5641" @default.
• W1769192511 abstract "Abstract We analyzed CD4+ T helper responses to wild-type (wt) and mutated (mut) p53 protein in normal and tumor-bearing mice. In normal mice, we observed that although some self-p53 determinants induced negative selection of p53-reactive CD4+ T cells, other p53 determinants (cryptic) were immunogenic. Next, BALB/c mice were inoculated with J774 syngeneic tumor cell line expressing mut p53. BALB/c tumor-bearing mice mounted potent CD4+ T cell responses to two formerly cryptic peptides on self-p53. This response was characterized by massive production of IL-5, a Th2-type lymphokine. Interestingly, we found that T cell response was induced by different p53 peptides depending upon the stage of cancer. Mut p53 gene was shown to contain a single mutation resulting in the substitution of a tyrosine by a histidine at position 231 of the protein. Two peptides corresponding to wt and mutated sequences of this region were synthesized. Both peptides bound to the MHC class II-presenting molecule (Ed) with similar affinities. However, only mut p53.225–239 induced T cell responses in normal BALB/c mice, a result strongly suggesting that high-affinity wt p53.225–239 autoreactive T cells had been eliminated in these mice. Surprisingly, CD4+ T cell responses to both mut and wt p53.225–239 peptides were recorded in J774 tumor-bearing mice, a phenomenon attributed to the recruitment of low-avidity p53.225–239 self-reactive T cells." @default.
• W1769192511 created "2016-06-24" @default.
• W1769192511 creator A5002197635 @default.
• W1769192511 creator A5006295233 @default.
• W1769192511 creator A5021223240 @default.
• W1769192511 creator A5028633953 @default.
• W1769192511 creator A5045774777 @default.
• W1769192511 creator A5073294164 @default.
• W1769192511 creator A5081134319 @default.
• W1769192511 creator A5088459365 @default.
• W1769192511 date "2000-06-01" @default.
• W1769192511 modified "2023-10-14" @default.
• W1769192511 title "CD4+ T Cell Responses to Self- and Mutated p53 Determinants During Tumorigenesis in Mice" @default.
• W1769192511 cites W120196646 @default.
• W1769192511 cites W1537788154 @default.
• W1769192511 cites W1579078560 @default.
• W1769192511 cites W1922148398 @default.
• W1769192511 cites W1987589866 @default.
• W1769192511 cites W1991494214 @default.
• W1769192511 cites W1999920664 @default.
• W1769192511 cites W2002171452 @default.
• W1769192511 cites W2007515141 @default.
• W1769192511 cites W2010363127 @default.
• W1769192511 cites W2012053348 @default.
• W1769192511 cites W2021124921 @default.
• W1769192511 cites W2025309264 @default.
• W1769192511 cites W2033048285 @default.
• W1769192511 cites W2034773156 @default.
• W1769192511 cites W2036851895 @default.
• W1769192511 cites W2040594411 @default.
• W1769192511 cites W2041679777 @default.
• W1769192511 cites W2042316019 @default.
• W1769192511 cites W2043745393 @default.
• W1769192511 cites W2051306981 @default.
• W1769192511 cites W2063366670 @default.
• W1769192511 cites W2065121753 @default.
• W1769192511 cites W2072541256 @default.
• W1769192511 cites W2073115356 @default.
• W1769192511 cites W2073535153 @default.
• W1769192511 cites W2078760290 @default.
• W1769192511 cites W2080692751 @default.
• W1769192511 cites W2083379652 @default.
• W1769192511 cites W2083500661 @default.
• W1769192511 cites W2092268147 @default.
• W1769192511 cites W2097009175 @default.
• W1769192511 cites W2099458553 @default.
• W1769192511 cites W2116293732 @default.
• W1769192511 cites W2116595225 @default.
• W1769192511 cites W2117749759 @default.
• W1769192511 cites W2119566867 @default.
• W1769192511 cites W2123450824 @default.
• W1769192511 cites W2123524669 @default.
• W1769192511 cites W2126844355 @default.
• W1769192511 cites W2127094135 @default.
• W1769192511 cites W2147597038 @default.
• W1769192511 cites W2163357710 @default.
• W1769192511 cites W4240018768 @default.
• W1769192511 cites W4253723837 @default.
• W1769192511 doi "https://doi.org/10.4049/jimmunol.164.11.5641" @default.
• W1769192511 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10820239" @default.
• W1769192511 hasPublicationYear "2000" @default.
• W1769192511 type Work @default.
• W1769192511 sameAs 1769192511 @default.
• W1769192511 citedByCount "28" @default.
• W1769192511 countsByYear W17691925112012 @default.
• W1769192511 countsByYear W17691925112013 @default.
• W1769192511 countsByYear W17691925112017 @default.
• W1769192511 countsByYear W17691925112020 @default.
• W1769192511 countsByYear W17691925112021 @default.
• W1769192511 crossrefType "journal-article" @default.
• W1769192511 hasAuthorship W1769192511A5002197635 @default.
• W1769192511 hasAuthorship W1769192511A5006295233 @default.
• W1769192511 hasAuthorship W1769192511A5021223240 @default.
• W1769192511 hasAuthorship W1769192511A5028633953 @default.
• W1769192511 hasAuthorship W1769192511A5045774777 @default.
• W1769192511 hasAuthorship W1769192511A5073294164 @default.
• W1769192511 hasAuthorship W1769192511A5081134319 @default.
• W1769192511 hasAuthorship W1769192511A5088459365 @default.
• W1769192511 hasBestOaLocation W17691925111 @default.
• W1769192511 hasConcept C104317684 @default.
• W1769192511 hasConcept C147483822 @default.
• W1769192511 hasConcept C153911025 @default.
• W1769192511 hasConcept C167672396 @default.
• W1769192511 hasConcept C179223381 @default.
• W1769192511 hasConcept C19317047 @default.
• W1769192511 hasConcept C203014093 @default.
• W1769192511 hasConcept C207936829 @default.
• W1769192511 hasConcept C2776090121 @default.
• W1769192511 hasConcept C501734568 @default.
• W1769192511 hasConcept C502942594 @default.
• W1769192511 hasConcept C55493867 @default.
• W1769192511 hasConcept C555283112 @default.
• W1769192511 hasConcept C86803240 @default.
• W1769192511 hasConcept C8891405 @default.
• W1769192511 hasConceptScore W1769192511C104317684 @default.
• W1769192511 hasConceptScore W1769192511C147483822 @default.
• W1769192511 hasConceptScore W1769192511C153911025 @default.
• W1769192511 hasConceptScore W1769192511C167672396 @default.

• next