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• W1769562990 abstract "Death is common in systemic inflammatory response syndrome (SIRS) or sepsis-induced multisystem organ failure and it has been thought that antioxidants such as N-acetylcysteine could be beneficial.We assessed the clinical effectiveness of intravenous N-acetylcysteine for the treatment of patients with SIRS or sepsis.We searched the following databases: Cochrane Central Register of Clinical Trials (CENTRAL) (The Cochrane Library 2011, Issue 12); MEDLINE (January 1950 to January 2012); EMBASE (January 1980 to January 2012); CINAHL (1982 to January 2012); the NHS Trusts Clinical Trials Register and Current Controlled Trials (www.controlled-trials.com); LILACS; KoreaMED; MEDCARIB; INDMED; PANTELEIMON; Ingenta; ISI Web of Knowledge and the National Trials Register to identify all relevant randomized controlled trials available for review.We included only randomized controlled trials (RCTs) in the meta-analysis.We independently performed study selection, quality assessment and data extraction. We estimated risk ratios (RR) for dichotomous outcomes. We measured statistical heterogeneity using the I(2) statistic.We included 41 fully published studies (2768 patients). Mortality was similar in the N-acetylcysteine group and the placebo group (RR 1.06, 95% CI 0.79 to 1.42; I(2) = 0%). Neither did N-acetylcysteine show any significant effect on length of stay, duration of mechanical ventilation or incidence of new organ failure. Early application of N-acetylcysteine to prevent the development of an oxidato-inflammatory response did not affect the outcome, nor did late application that is after 24 hours of developing symptoms. Late application was associated with cardiovascular instability.Overall, this meta-analysis puts doubt on the safety and utility of intravenous N-acetylcysteine as an adjuvant therapy in SIRS and sepsis. At best, N-acetylcysteine is ineffective in reducing mortality and complications in this patient population. At worst, it can be harmful, especially when administered later than 24 hours after the onset of symptoms, by causing cardiovascular depression. Unless future RCTs provide evidence of treatment effect, clinicians should not routinely use intravenous N-acetylcysteine in SIRS or sepsis and academics should not promote its use." @default.
• W1769562990 created "2016-06-24" @default.
• W1769562990 creator A5009577840 @default.
• W1769562990 creator A5033389583 @default.
• W1769562990 creator A5035285679 @default.
• W1769562990 date "2012-09-12" @default.
• W1769562990 modified "2023-10-16" @default.
• W1769562990 title "N-acetylcysteine for sepsis and systemic inflammatory response in adults" @default.
• W1769562990 cites W122610404 @default.
• W1769562990 cites W1502248524 @default.
• W1769562990 cites W1524926009 @default.
• W1769562990 cites W1537972189 @default.
• W1769562990 cites W1604040652 @default.
• W1769562990 cites W1742579017 @default.
• W1769562990 cites W1755665316 @default.
• W1769562990 cites W1949926804 @default.
• W1769562990 cites W1964173869 @default.
• W1769562990 cites W1967417261 @default.
• W1769562990 cites W1973180856 @default.
• W1769562990 cites W1975283664 @default.
• W1769562990 cites W1978339533 @default.
• W1769562990 cites W1982499853 @default.
• W1769562990 cites W1983626006 @default.
• W1769562990 cites W1983881370 @default.
• W1769562990 cites W1983914913 @default.
• W1769562990 cites W1984052453 @default.
• W1769562990 cites W1985763791 @default.
• W1769562990 cites W1988274521 @default.
• W1769562990 cites W1988424962 @default.
• W1769562990 cites W1988852513 @default.
• W1769562990 cites W1989319206 @default.
• W1769562990 cites W1992291863 @default.
• W1769562990 cites W1993368731 @default.
• W1769562990 cites W1994185223 @default.
• W1769562990 cites W1994329540 @default.
• W1769562990 cites W1995317658 @default.
• W1769562990 cites W1995614558 @default.
• W1769562990 cites W1999825283 @default.
• W1769562990 cites W2000000986 @default.
• W1769562990 cites W2002641335 @default.
• W1769562990 cites W2002681693 @default.
• W1769562990 cites W2006157122 @default.
• W1769562990 cites W2006461547 @default.
• W1769562990 cites W2008004149 @default.
• W1769562990 cites W2008467867 @default.
• W1769562990 cites W2013404747 @default.
• W1769562990 cites W2013657085 @default.
• W1769562990 cites W2016253916 @default.
• W1769562990 cites W2017006924 @default.
• W1769562990 cites W2024295698 @default.
• W1769562990 cites W2029199491 @default.
• W1769562990 cites W2037159487 @default.
• W1769562990 cites W2041017075 @default.
• W1769562990 cites W2042206193 @default.
• W1769562990 cites W2043898540 @default.
• W1769562990 cites W2046633151 @default.
• W1769562990 cites W2049556543 @default.
• W1769562990 cites W2053369078 @default.
• W1769562990 cites W2053491289 @default.
• W1769562990 cites W2054083604 @default.
• W1769562990 cites W2057533801 @default.
• W1769562990 cites W2064239029 @default.
• W1769562990 cites W2064344745 @default.
• W1769562990 cites W2067361515 @default.
• W1769562990 cites W2068959829 @default.
• W1769562990 cites W2070418093 @default.
• W1769562990 cites W2071095297 @default.
• W1769562990 cites W2072588990 @default.
• W1769562990 cites W2074236325 @default.
• W1769562990 cites W2074466433 @default.
• W1769562990 cites W2076151500 @default.
• W1769562990 cites W2079215889 @default.
• W1769562990 cites W2081301770 @default.
• W1769562990 cites W2082681464 @default.
• W1769562990 cites W2085174769 @default.
• W1769562990 cites W2085995950 @default.
• W1769562990 cites W2093303850 @default.
• W1769562990 cites W2093737679 @default.
• W1769562990 cites W2094953524 @default.
• W1769562990 cites W2095080951 @default.
• W1769562990 cites W2098451760 @default.
• W1769562990 cites W2106201098 @default.
• W1769562990 cites W2108623045 @default.
• W1769562990 cites W2109003787 @default.
• W1769562990 cites W2109661386 @default.
• W1769562990 cites W2115626204 @default.
• W1769562990 cites W2121053994 @default.
• W1769562990 cites W2126930838 @default.
• W1769562990 cites W2127157208 @default.
• W1769562990 cites W2133851744 @default.
• W1769562990 cites W2134401145 @default.
• W1769562990 cites W2134676939 @default.
• W1769562990 cites W2138579645 @default.
• W1769562990 cites W2139411202 @default.
• W1769562990 cites W2140840063 @default.
• W1769562990 cites W2145147082 @default.
• W1769562990 cites W2151272921 @default.
• W1769562990 cites W2152325979 @default.
• W1769562990 cites W2156237600 @default.
• W1769562990 cites W2157305642 @default.

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