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- W1769601709 abstract "Abstract Background Development of the enteric nervous system (ENS) requires interactions between migrating neural crest cells and the nascent gastrointestinal tract that are dependent upon genes expressed by both cell compartments. Hlx , a homeobox transcription factor gene that is expressed in mouse intestinal and hepatic mesenchyme, is required for normal embryonic growth of intestine and liver, and the Hlx -/- genotype is embryonic lethal. We hypothesized that Hlx is required for ENS development. Results Enteric neurons were identified in Hlx +/+ and Hlx -/- mouse embryos by immunostaining of embryo sections for the neural markers PGP9.5 and Phox2b, or by staining for β-galactosidase in whole-mount embryos containing the dopamine β-hydroxylase-n LacZ transgene. In Hlx +/+ embryos, neural crest cells/enteric neurons have moved from the stomach into the intestine by E10.5. By contrast, neural crest cells/enteric neurons remain largely restricted to the lateral stomach mesenchyme of Hlx -/- embryos, with only a few scattered neural crest cells/enteric neurons in the intestine between E10.5–16.5. Conclusion The Hlx homeobox transcription factor is required for early aspects of ENS development." @default.
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- W1769601709 date "2006-07-19" @default.
- W1769601709 modified "2023-10-12" @default.
- W1769601709 title "The Hlx homeobox transcription factor is required early in enteric nervous system development" @default.
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- W1769601709 doi "https://doi.org/10.1186/1471-213x-6-33" @default.
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