Matches in SemOpenAlex for { <https://semopenalex.org/work/W1769775274> ?p ?o ?g. }
- W1769775274 endingPage "1632" @default.
- W1769775274 startingPage "1627" @default.
- W1769775274 abstract "Heme oxygenase-1 (HO-1) has a protective role against ischemia/reperfusion (I/R) injury. We produced an HO-1 fusion protein mediated by cell penetrated peptide PEP-1, also known as PEP-1–HO-1 fusion protein, and investigated its role in renal I/R injury in rats. Male Sprague-Dawley rats were subjected to 45 minutes of ischemia by occluding the bilateral renal arteries and 6 hours of reperfusion to prepare the model of renal I/R. Animals were randomized to receive PEP-1–HO-1 fusion protein or equal volume of physiologic saline 30 minutes before ischemia. Administration of PEP-1–HO-1 fusion protein resulted in a significant increase in HO-1 expression. His-probe expression (1 part of the PEP-1–HO-1 fusion protein) was only observed in PEP-1–HO-1–treated animals. I/R caused renal dysfunction and increases in malondialdehyde level and cell apoptosis, and decreased superoxide dismutase activity. Treatment of PEP-1–HO-1 fusion protein reversed these changes. Furthermore, administration of PEP-1–HO-1 inhibited the I/R-induced increase in nuclear factor-κB activation. These findings suggest that transduction of PEP-1–HO-1 attenuates renal I/R injury in rats, which might be partly attributable to its antioxidant and antiapoptotic effects." @default.
- W1769775274 created "2016-06-24" @default.
- W1769775274 creator A5012725634 @default.
- W1769775274 creator A5029712785 @default.
- W1769775274 creator A5036184685 @default.
- W1769775274 creator A5043232519 @default.
- W1769775274 creator A5069616329 @default.
- W1769775274 date "2015-07-01" @default.
- W1769775274 modified "2023-09-23" @default.
- W1769775274 title "Transduced Heme Oxygenase-1 Fusion Protein Reduces Renal Ischemia/Reperfusion Injury Through Its Antioxidant and Antiapoptotic Roles in Rats" @default.
- W1769775274 cites W1792053333 @default.
- W1769775274 cites W1967353947 @default.
- W1769775274 cites W1970684145 @default.
- W1769775274 cites W1971946694 @default.
- W1769775274 cites W1995615445 @default.
- W1769775274 cites W1998878763 @default.
- W1769775274 cites W2016597337 @default.
- W1769775274 cites W2025616153 @default.
- W1769775274 cites W2034437306 @default.
- W1769775274 cites W2036526595 @default.
- W1769775274 cites W2052637380 @default.
- W1769775274 cites W2053984974 @default.
- W1769775274 cites W2061607183 @default.
- W1769775274 cites W2088767843 @default.
- W1769775274 cites W2089193206 @default.
- W1769775274 cites W2103002981 @default.
- W1769775274 cites W2104548844 @default.
- W1769775274 cites W2110859044 @default.
- W1769775274 cites W2111856478 @default.
- W1769775274 cites W2139423543 @default.
- W1769775274 cites W2144196643 @default.
- W1769775274 cites W2148924453 @default.
- W1769775274 cites W2164574814 @default.
- W1769775274 cites W2315622907 @default.
- W1769775274 cites W2410537909 @default.
- W1769775274 doi "https://doi.org/10.1016/j.transproceed.2015.04.098" @default.
- W1769775274 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26293025" @default.
- W1769775274 hasPublicationYear "2015" @default.
- W1769775274 type Work @default.
- W1769775274 sameAs 1769775274 @default.
- W1769775274 citedByCount "4" @default.
- W1769775274 countsByYear W17697752742016 @default.
- W1769775274 countsByYear W17697752742019 @default.
- W1769775274 countsByYear W17697752742020 @default.
- W1769775274 countsByYear W17697752742021 @default.
- W1769775274 crossrefType "journal-article" @default.
- W1769775274 hasAuthorship W1769775274A5012725634 @default.
- W1769775274 hasAuthorship W1769775274A5029712785 @default.
- W1769775274 hasAuthorship W1769775274A5036184685 @default.
- W1769775274 hasAuthorship W1769775274A5043232519 @default.
- W1769775274 hasAuthorship W1769775274A5069616329 @default.
- W1769775274 hasConcept C104317684 @default.
- W1769775274 hasConcept C123894998 @default.
- W1769775274 hasConcept C126322002 @default.
- W1769775274 hasConcept C134018914 @default.
- W1769775274 hasConcept C181199279 @default.
- W1769775274 hasConcept C185592680 @default.
- W1769775274 hasConcept C190283241 @default.
- W1769775274 hasConcept C2775838275 @default.
- W1769775274 hasConcept C2776151105 @default.
- W1769775274 hasConcept C2776217839 @default.
- W1769775274 hasConcept C2778004101 @default.
- W1769775274 hasConcept C2778401633 @default.
- W1769775274 hasConcept C2779219270 @default.
- W1769775274 hasConcept C2780091579 @default.
- W1769775274 hasConcept C2780114680 @default.
- W1769775274 hasConcept C40767141 @default.
- W1769775274 hasConcept C541997718 @default.
- W1769775274 hasConcept C55493867 @default.
- W1769775274 hasConcept C71924100 @default.
- W1769775274 hasConcept C98274493 @default.
- W1769775274 hasConceptScore W1769775274C104317684 @default.
- W1769775274 hasConceptScore W1769775274C123894998 @default.
- W1769775274 hasConceptScore W1769775274C126322002 @default.
- W1769775274 hasConceptScore W1769775274C134018914 @default.
- W1769775274 hasConceptScore W1769775274C181199279 @default.
- W1769775274 hasConceptScore W1769775274C185592680 @default.
- W1769775274 hasConceptScore W1769775274C190283241 @default.
- W1769775274 hasConceptScore W1769775274C2775838275 @default.
- W1769775274 hasConceptScore W1769775274C2776151105 @default.
- W1769775274 hasConceptScore W1769775274C2776217839 @default.
- W1769775274 hasConceptScore W1769775274C2778004101 @default.
- W1769775274 hasConceptScore W1769775274C2778401633 @default.
- W1769775274 hasConceptScore W1769775274C2779219270 @default.
- W1769775274 hasConceptScore W1769775274C2780091579 @default.
- W1769775274 hasConceptScore W1769775274C2780114680 @default.
- W1769775274 hasConceptScore W1769775274C40767141 @default.
- W1769775274 hasConceptScore W1769775274C541997718 @default.
- W1769775274 hasConceptScore W1769775274C55493867 @default.
- W1769775274 hasConceptScore W1769775274C71924100 @default.
- W1769775274 hasConceptScore W1769775274C98274493 @default.
- W1769775274 hasFunder F4320321001 @default.
- W1769775274 hasIssue "6" @default.
- W1769775274 hasLocation W17697752741 @default.
- W1769775274 hasLocation W17697752742 @default.
- W1769775274 hasOpenAccess W1769775274 @default.
- W1769775274 hasPrimaryLocation W17697752741 @default.
- W1769775274 hasRelatedWork W1993548188 @default.