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• W1769793530 abstract "<h3>BACKGROUND AND PURPOSE:</h3> Dynamic contrast-enhanced MR imaging parameters can be biased by poor measurement of the vascular input function. We have compared the diagnostic accuracy of dynamic contrast-enhanced MR imaging by using a phase-derived vascular input function and “bookend” T1 measurements with DSC MR imaging for preoperative grading of astrocytomas. <h3>MATERIALS AND METHODS:</h3> This prospective study included 48 patients with a new pathologic diagnosis of an astrocytoma. Preoperative MR imaging was performed at 3T, which included 2 injections of 5-mL gadobutrol for dynamic contrast-enhanced and DSC MR imaging. During dynamic contrast-enhanced MR imaging, both magnitude and phase images were acquired to estimate plasma volume obtained from phase-derived vascular input function (Vp_Φ) and volume transfer constant obtained from phase-derived vascular input function (<i>K</i>^trans_Φ) as well as plasma volume obtained from magnitude-derived vascular input function (Vp_SI) and volume transfer constant obtained from magnitude-derived vascular input function (<i>K</i>^trans_SI). From DSC MR imaging, corrected relative CBV was computed. Four ROIs were placed over the solid part of the tumor, and the highest value among the ROIs was recorded. A Mann-Whitney <i>U</i> test was used to test for difference between grades. Diagnostic accuracy was assessed by using receiver operating characteristic analysis. <h3>RESULTS:</h3> Vp_ Φ and <i>K</i>^trans_Φ values were lower for grade II compared with grade III astrocytomas (<i>P</i> < .05). Vp_SI and <i>K</i>^trans_SI were not significantly different between grade II and grade III astrocytomas (<i>P</i> = .08–0.15). Relative CBV and dynamic contrast-enhanced MR imaging parameters except for <i>K</i>^trans_SI were lower for grade III compared with grade IV (<i>P</i> ≤ .05). In differentiating low- and high-grade astrocytomas, we found no statistically significant difference in diagnostic accuracy between relative CBV and dynamic contrast-enhanced MR imaging parameters. <h3>CONCLUSIONS:</h3> In the preoperative grading of astrocytomas, the diagnostic accuracy of dynamic contrast-enhanced MR imaging parameters is similar to that of relative CBV." @default.
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• W1769793530 date "2015-07-30" @default.
• W1769793530 modified "2023-09-30" @default.
• W1769793530 title "Comparison of the Diagnostic Accuracy of DSC- and Dynamic Contrast-Enhanced MRI in the Preoperative Grading of Astrocytomas" @default.
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• W1769793530 doi "https://doi.org/10.3174/ajnr.a4398" @default.
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