FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1769887965> ?p ?o ?g. }

• W1769887965 endingPage "57" @default.
• W1769887965 startingPage "3348" @default.
• W1769887965 abstract "Stromal cell cultures obtained from human endometrium were treated repetitively with N-methyl-N'-nitro-N-nitrosoguanidine in vitro at concentrations ranging from 0.5 to 4.0 micrograms/ml, and alterations in growth potential and morphology were analyzed. A single exposure to the carcinogen resulted in morphological evidence of toxicity and reductions in growth rates, plating efficiency, and saturation density as compared to solvent-treated control cells. Cytotoxicity was reduced after additional exposures to the carcinogen. Following repetitive treatments with N-methyl-N'-nitro-N-nitrosoguanidine, human endometrial stromal cells developed enhanced growth potential, the capacity to form macroscopic colonies in soft agar, and elevated gamma-glutamyltranspeptidase activity. Carcinogen-treated cells displayed atypical morphology characterized by irregularities in cell and nuclear size and shape, large bizarre nucleoli, increased nuclear:cytoplasmic ratios, and cellular crowding. Control cells did not display altered morphology or growth parameters even following multiple exposures to solvent and repetitive subculturing. These alterations in growth potential and morphology suggest that the cells are progressing towards preneoplastic and perhaps neoplastic transformation in vitro." @default.
• W1769887965 created "2016-06-24" @default.
• W1769887965 creator A5024666494 @default.
• W1769887965 creator A5031746829 @default.
• W1769887965 creator A5073854518 @default.
• W1769887965 date "1983-07-01" @default.
• W1769887965 modified "2023-09-23" @default.
• W1769887965 title "Alterations of human endometrial stromal cells produced by N-methyl-N'-nitro-N-nitrosoguanidine." @default.
• W1769887965 cites W1488430785 @default.
• W1769887965 cites W1512094340 @default.
• W1769887965 cites W1520102293 @default.
• W1769887965 cites W1520867883 @default.
• W1769887965 cites W1573679990 @default.
• W1769887965 cites W1594171327 @default.
• W1769887965 cites W1771050785 @default.
• W1769887965 cites W1897556833 @default.
• W1769887965 cites W1900658750 @default.
• W1769887965 cites W1936746440 @default.
• W1769887965 cites W1962380636 @default.
• W1769887965 cites W1975023230 @default.
• W1769887965 cites W1978609567 @default.
• W1769887965 cites W1997653052 @default.
• W1769887965 cites W1999130793 @default.
• W1769887965 cites W2008480569 @default.
• W1769887965 cites W2009384953 @default.
• W1769887965 cites W2016544181 @default.
• W1769887965 cites W2018830953 @default.
• W1769887965 cites W2020179235 @default.
• W1769887965 cites W2020873813 @default.
• W1769887965 cites W2039074795 @default.
• W1769887965 cites W2049154530 @default.
• W1769887965 cites W2055013283 @default.
• W1769887965 cites W2073098405 @default.
• W1769887965 cites W2107813583 @default.
• W1769887965 cites W2139947086 @default.
• W1769887965 cites W2162031414 @default.
• W1769887965 cites W2252338800 @default.
• W1769887965 cites W2268872623 @default.
• W1769887965 cites W2269942396 @default.
• W1769887965 cites W2275395836 @default.
• W1769887965 cites W2278225743 @default.
• W1769887965 cites W2292599581 @default.
• W1769887965 cites W2413148796 @default.
• W1769887965 cites W259588263 @default.
• W1769887965 cites W3026311663 @default.
• W1769887965 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6133612" @default.
• W1769887965 hasPublicationYear "1983" @default.
• W1769887965 type Work @default.
• W1769887965 sameAs 1769887965 @default.
• W1769887965 citedByCount "6" @default.
• W1769887965 crossrefType "journal-article" @default.
• W1769887965 hasAuthorship W1769887965A5024666494 @default.
• W1769887965 hasAuthorship W1769887965A5031746829 @default.
• W1769887965 hasAuthorship W1769887965A5073854518 @default.
• W1769887965 hasConcept C109316439 @default.
• W1769887965 hasConcept C114246631 @default.
• W1769887965 hasConcept C1491633281 @default.
• W1769887965 hasConcept C153911025 @default.
• W1769887965 hasConcept C16685009 @default.
• W1769887965 hasConcept C16930146 @default.
• W1769887965 hasConcept C185592680 @default.
• W1769887965 hasConcept C202751555 @default.
• W1769887965 hasConcept C502942594 @default.
• W1769887965 hasConcept C54355233 @default.
• W1769887965 hasConcept C55493867 @default.
• W1769887965 hasConcept C62112901 @default.
• W1769887965 hasConcept C71924100 @default.
• W1769887965 hasConcept C81885089 @default.
• W1769887965 hasConcept C86803240 @default.
• W1769887965 hasConceptScore W1769887965C109316439 @default.
• W1769887965 hasConceptScore W1769887965C114246631 @default.
• W1769887965 hasConceptScore W1769887965C1491633281 @default.
• W1769887965 hasConceptScore W1769887965C153911025 @default.
• W1769887965 hasConceptScore W1769887965C16685009 @default.
• W1769887965 hasConceptScore W1769887965C16930146 @default.
• W1769887965 hasConceptScore W1769887965C185592680 @default.
• W1769887965 hasConceptScore W1769887965C202751555 @default.
• W1769887965 hasConceptScore W1769887965C502942594 @default.
• W1769887965 hasConceptScore W1769887965C54355233 @default.
• W1769887965 hasConceptScore W1769887965C55493867 @default.
• W1769887965 hasConceptScore W1769887965C62112901 @default.
• W1769887965 hasConceptScore W1769887965C71924100 @default.
• W1769887965 hasConceptScore W1769887965C81885089 @default.
• W1769887965 hasConceptScore W1769887965C86803240 @default.
• W1769887965 hasIssue "7" @default.
• W1769887965 hasLocation W17698879651 @default.
• W1769887965 hasOpenAccess W1769887965 @default.
• W1769887965 hasPrimaryLocation W17698879651 @default.
• W1769887965 hasRelatedWork W2012910522 @default.
• W1769887965 hasRelatedWork W2013912939 @default.
• W1769887965 hasRelatedWork W2043407503 @default.
• W1769887965 hasRelatedWork W2084038436 @default.
• W1769887965 hasRelatedWork W2376379550 @default.
• W1769887965 hasRelatedWork W2388451095 @default.
• W1769887965 hasRelatedWork W2413532914 @default.
• W1769887965 hasRelatedWork W2464301138 @default.
• W1769887965 hasRelatedWork W3019445930 @default.
• W1769887965 hasRelatedWork W3046142566 @default.

• next