Matches in SemOpenAlex for { <https://semopenalex.org/work/W1770306429> ?p ?o ?g. }
- W1770306429 endingPage "112" @default.
- W1770306429 startingPage "97" @default.
- W1770306429 abstract "Particles capable of homing and adhering to specific vascular biomarkers have potential as fundamental tools in drug delivery for mediation of a wide variety of pathologies, including inflammation, thrombosis, and pulmonary disorders. The presentation of affinity ligands on the surface of a particle provides a means of targeting the particle to sites of therapeutic interest, but a host of other factors come into play in determining the targeting capacity of the particle. This review presents a summary of several key considerations in nano- and microparticle design that modulate targeted delivery without directly altering epitope-specific affinity. Namely, we describe the effect of factors in definition of the base carrier (including shape, size, and flexibility) on the capacity of carriers to access, adhere to, and integrate in target biological milieus. Furthermore, we present a summary of fundamental dynamics of carrier behavior in circulation, taking into account interactions with cells in circulation and the role of hemodynamics in mediating the direction of carriers to target sites. Finally, we note non-affinity aspects to uptake and intracellular trafficking of carriers in target cells. In total, recent findings presented here may offer an opportunity to capitalize on mitigating factors in the behavior of ligand-targeted carriers in order to optimize targeting." @default.
- W1770306429 created "2016-06-24" @default.
- W1770306429 creator A5006231842 @default.
- W1770306429 creator A5022924802 @default.
- W1770306429 creator A5044479012 @default.
- W1770306429 creator A5060760443 @default.
- W1770306429 creator A5067701831 @default.
- W1770306429 creator A5087180621 @default.
- W1770306429 date "2016-04-01" @default.
- W1770306429 modified "2023-10-16" @default.
- W1770306429 title "Non-affinity factors modulating vascular targeting of nano- and microcarriers" @default.
- W1770306429 cites W137353534 @default.
- W1770306429 cites W152757686 @default.
- W1770306429 cites W1547799458 @default.
- W1770306429 cites W1636022800 @default.
- W1770306429 cites W1690464810 @default.
- W1770306429 cites W1709272109 @default.
- W1770306429 cites W1871308790 @default.
- W1770306429 cites W1872315511 @default.
- W1770306429 cites W1879471427 @default.
- W1770306429 cites W1928407788 @default.
- W1770306429 cites W1965097716 @default.
- W1770306429 cites W1967043468 @default.
- W1770306429 cites W1968709827 @default.
- W1770306429 cites W1968799061 @default.
- W1770306429 cites W1968898129 @default.
- W1770306429 cites W1968982832 @default.
- W1770306429 cites W1970457446 @default.
- W1770306429 cites W1971094951 @default.
- W1770306429 cites W1973055559 @default.
- W1770306429 cites W1973252400 @default.
- W1770306429 cites W1974158357 @default.
- W1770306429 cites W1975088956 @default.
- W1770306429 cites W1975252318 @default.
- W1770306429 cites W1975272121 @default.
- W1770306429 cites W1975341277 @default.
- W1770306429 cites W1976655375 @default.
- W1770306429 cites W1977457835 @default.
- W1770306429 cites W1978002868 @default.
- W1770306429 cites W1979337789 @default.
- W1770306429 cites W1981248837 @default.
- W1770306429 cites W1981594687 @default.
- W1770306429 cites W1982228392 @default.
- W1770306429 cites W1982247713 @default.
- W1770306429 cites W1982748428 @default.
- W1770306429 cites W1983321855 @default.
- W1770306429 cites W1984005906 @default.
- W1770306429 cites W1985037778 @default.
- W1770306429 cites W1985048358 @default.
- W1770306429 cites W1987654715 @default.
- W1770306429 cites W1987769702 @default.
- W1770306429 cites W1990556507 @default.
- W1770306429 cites W1993029332 @default.
- W1770306429 cites W1994761503 @default.
- W1770306429 cites W1997064778 @default.
- W1770306429 cites W1997435827 @default.
- W1770306429 cites W1998531158 @default.
- W1770306429 cites W1998688476 @default.
- W1770306429 cites W2000282355 @default.
- W1770306429 cites W2000654459 @default.
- W1770306429 cites W2001824430 @default.
- W1770306429 cites W2002306218 @default.
- W1770306429 cites W2003291344 @default.
- W1770306429 cites W2003311493 @default.
- W1770306429 cites W2003336829 @default.
- W1770306429 cites W2004619992 @default.
- W1770306429 cites W2004893561 @default.
- W1770306429 cites W2006139547 @default.
- W1770306429 cites W2006474652 @default.
- W1770306429 cites W2006789961 @default.
- W1770306429 cites W2007087804 @default.
- W1770306429 cites W2008998756 @default.
- W1770306429 cites W2009259358 @default.
- W1770306429 cites W2010202412 @default.
- W1770306429 cites W2011001489 @default.
- W1770306429 cites W2013470095 @default.
- W1770306429 cites W2015497529 @default.
- W1770306429 cites W2015752928 @default.
- W1770306429 cites W2016936741 @default.
- W1770306429 cites W2017611825 @default.
- W1770306429 cites W2018172263 @default.
- W1770306429 cites W2018880356 @default.
- W1770306429 cites W2019165947 @default.
- W1770306429 cites W2019207861 @default.
- W1770306429 cites W2020090114 @default.
- W1770306429 cites W2022948419 @default.
- W1770306429 cites W2024787650 @default.
- W1770306429 cites W2025471734 @default.
- W1770306429 cites W2027052987 @default.
- W1770306429 cites W2029435311 @default.
- W1770306429 cites W2030574023 @default.
- W1770306429 cites W2031094501 @default.
- W1770306429 cites W2032088674 @default.
- W1770306429 cites W2032760352 @default.
- W1770306429 cites W2032931290 @default.
- W1770306429 cites W2033663157 @default.
- W1770306429 cites W2034248554 @default.
- W1770306429 cites W2036132667 @default.