Matches in SemOpenAlex for { <https://semopenalex.org/work/W1770492158> ?p ?o ?g. }
- W1770492158 endingPage "206" @default.
- W1770492158 startingPage "199" @default.
- W1770492158 abstract "Objective: The present study was aimed at the fabrication and characterization of solid lipid based microspheres (SLM) of Ketoprofen (KPF) and comparing its anti-inflammatory potential with the marketed formulation. Methods: Stearic acid as a lipid and tween 20, 80, span 20 and 80 as surfactants (at various concentrations) were utilized for formulation of topical delivery. Microparticles were successfully fabricated (0.71-3.12 µm) by hot melt microencapsulation technique and were characterised by photomicroscope, FTIR, scanning electron surface morphology, particle size analysis, zeta potential, fluorescent microscopy and In-vitro drug release studies followed by In-vitro and In-vivo anti-inflammatory studies. Results: Results revealed that tween 80 resulted in exceptional KPF entrapment efficiency of 82.6% with spherical rough surface morphology. In-vitro drug release showed the initial burst release of 47% upto 2h followed by sustained release of 70% for 12h. By employing drug release kinetic modelling, formulations were found to obey Higuchi model and Korsmeyer-Peppas model. Further the In-vitro permeation study of optimized gel formulation represented better drug uptake through rat skin in comparison to marketed product. Finally, SLMs were found to possess superior In-vitro and In-vivo anti-inflammatory potentials when compared to marketed formulation. Conclusion: SLMs proved to be promising drug carrier system for KPF topical delivery as they possessed the desirable particle size with high ability for drug entrapment with sustained anti-inflammatory effect." @default.
- W1770492158 created "2016-06-24" @default.
- W1770492158 creator A5038502278 @default.
- W1770492158 creator A5069604973 @default.
- W1770492158 creator A5081769974 @default.
- W1770492158 creator A5082715070 @default.
- W1770492158 date "2015-08-14" @default.
- W1770492158 modified "2023-09-24" @default.
- W1770492158 title "TOPICAL GEL INCORPORATED WITH NON-IONIC SURFACTANT BASED SOLID LIPID MICROSPHERES OF KETOPROFEN: PHYSICOCHEMICAL ANALYSIS AND ANTI-INFLAMMATORY EVALUATION" @default.
- W1770492158 cites W1480805659 @default.
- W1770492158 cites W1579046626 @default.
- W1770492158 cites W1847827132 @default.
- W1770492158 cites W1973685311 @default.
- W1770492158 cites W1977072597 @default.
- W1770492158 cites W1978647910 @default.
- W1770492158 cites W1983473009 @default.
- W1770492158 cites W2003530563 @default.
- W1770492158 cites W2006803867 @default.
- W1770492158 cites W2015289563 @default.
- W1770492158 cites W2016181184 @default.
- W1770492158 cites W2035037307 @default.
- W1770492158 cites W2040380614 @default.
- W1770492158 cites W2041547286 @default.
- W1770492158 cites W2044985759 @default.
- W1770492158 cites W2047372391 @default.
- W1770492158 cites W2065254628 @default.
- W1770492158 cites W2074832039 @default.
- W1770492158 cites W2080390434 @default.
- W1770492158 cites W2080430067 @default.
- W1770492158 cites W2081834609 @default.
- W1770492158 cites W2083083278 @default.
- W1770492158 cites W2083473451 @default.
- W1770492158 cites W2086130473 @default.
- W1770492158 cites W2106585418 @default.
- W1770492158 cites W2112528692 @default.
- W1770492158 cites W2142573506 @default.
- W1770492158 cites W2317888114 @default.
- W1770492158 hasPublicationYear "2015" @default.
- W1770492158 type Work @default.
- W1770492158 sameAs 1770492158 @default.
- W1770492158 citedByCount "3" @default.
- W1770492158 countsByYear W17704921582016 @default.
- W1770492158 crossrefType "journal-article" @default.
- W1770492158 hasAuthorship W1770492158A5038502278 @default.
- W1770492158 hasAuthorship W1770492158A5069604973 @default.
- W1770492158 hasAuthorship W1770492158A5081769974 @default.
- W1770492158 hasAuthorship W1770492158A5082715070 @default.
- W1770492158 hasConcept C127413603 @default.
- W1770492158 hasConcept C147789679 @default.
- W1770492158 hasConcept C150903083 @default.
- W1770492158 hasConcept C155672457 @default.
- W1770492158 hasConcept C171250308 @default.
- W1770492158 hasConcept C178790620 @default.
- W1770492158 hasConcept C185592680 @default.
- W1770492158 hasConcept C187530423 @default.
- W1770492158 hasConcept C189942447 @default.
- W1770492158 hasConcept C192562407 @default.
- W1770492158 hasConcept C199529486 @default.
- W1770492158 hasConcept C202751555 @default.
- W1770492158 hasConcept C207001950 @default.
- W1770492158 hasConcept C2779516699 @default.
- W1770492158 hasConcept C2779820397 @default.
- W1770492158 hasConcept C2780035454 @default.
- W1770492158 hasConcept C2780744026 @default.
- W1770492158 hasConcept C41625074 @default.
- W1770492158 hasConcept C42360764 @default.
- W1770492158 hasConcept C43617362 @default.
- W1770492158 hasConcept C50670333 @default.
- W1770492158 hasConcept C55493867 @default.
- W1770492158 hasConcept C58226133 @default.
- W1770492158 hasConcept C71924100 @default.
- W1770492158 hasConcept C86181022 @default.
- W1770492158 hasConcept C86803240 @default.
- W1770492158 hasConcept C98274493 @default.
- W1770492158 hasConceptScore W1770492158C127413603 @default.
- W1770492158 hasConceptScore W1770492158C147789679 @default.
- W1770492158 hasConceptScore W1770492158C150903083 @default.
- W1770492158 hasConceptScore W1770492158C155672457 @default.
- W1770492158 hasConceptScore W1770492158C171250308 @default.
- W1770492158 hasConceptScore W1770492158C178790620 @default.
- W1770492158 hasConceptScore W1770492158C185592680 @default.
- W1770492158 hasConceptScore W1770492158C187530423 @default.
- W1770492158 hasConceptScore W1770492158C189942447 @default.
- W1770492158 hasConceptScore W1770492158C192562407 @default.
- W1770492158 hasConceptScore W1770492158C199529486 @default.
- W1770492158 hasConceptScore W1770492158C202751555 @default.
- W1770492158 hasConceptScore W1770492158C207001950 @default.
- W1770492158 hasConceptScore W1770492158C2779516699 @default.
- W1770492158 hasConceptScore W1770492158C2779820397 @default.
- W1770492158 hasConceptScore W1770492158C2780035454 @default.
- W1770492158 hasConceptScore W1770492158C2780744026 @default.
- W1770492158 hasConceptScore W1770492158C41625074 @default.
- W1770492158 hasConceptScore W1770492158C42360764 @default.
- W1770492158 hasConceptScore W1770492158C43617362 @default.
- W1770492158 hasConceptScore W1770492158C50670333 @default.
- W1770492158 hasConceptScore W1770492158C55493867 @default.
- W1770492158 hasConceptScore W1770492158C58226133 @default.
- W1770492158 hasConceptScore W1770492158C71924100 @default.