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• W177060896 abstract "Research Article1 May 1983free access Specific attachment of desmin filaments to desmosomal plaques in cardiac myocytes. J. Kartenbeck J. Kartenbeck Search for more papers by this author W.W. Franke W.W. Franke Search for more papers by this author J.G. Moser J.G. Moser Search for more papers by this author U. Stoffels U. Stoffels Search for more papers by this author J. Kartenbeck J. Kartenbeck Search for more papers by this author W.W. Franke W.W. Franke Search for more papers by this author J.G. Moser J.G. Moser Search for more papers by this author U. Stoffels U. Stoffels Search for more papers by this author Author Information J. Kartenbeck, W.W. Franke, J.G. Moser and U. Stoffels The EMBO Journal (1983)2:735-742https://doi.org/10.1002/j.1460-2075.1983.tb01493.x PDFDownload PDF of article text and main figures. ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinked InMendeleyWechatReddit Figures & Info Intercellular junctions which are similar in ultrastructure and protein composition to typical desmosomes have so far only been found in epithelial cells and in heart tissue, specifically in the intercalated disks of cardiac myocytes and at cell boundaries between Purkinje fiber cells. In epithelial cells the cytoplasmic side of desmosomes, the ‘desmosomal plaque’, represents a specific attachment structure for the anchorage of intermediate filaments (IF) of the cytokeratin type. Cardiac myocytes do not contain cytokeratin filaments. In primary cultures of rat cardiac myocytes, we have examined by immunofluorescence and electron microscopy, using single and double label techniques, whether other types of IF are attached to the desmosomal plaques of the heart. Antibodies to desmoplakin, the major protein of the desmosomal plaque, have been used to label specifically the desmosomal plaques. It is shown that the desmoplakin-containing structures are often associated with IF stained by antibodies to desmin, i.e., the characteristic type of IF present in these cells. Like cytokeratin filaments in epithelial cells, desmin filaments attach laterally to the desmosomal plaque. They also remain attached to these plaques after endocytotic internalization of desmosomal domains by treatment of the cells with EGTA. These desmin filaments do not appear to attach to junctions of the fascia adherens type and to nexuses (gap junctions). These observations show that anchorage at desmosomal plaques is not restricted to IF of the cytokeratin type and that IF composed of either cytokeratin or desmin, specifically attach, in a lateral fashion, to desmoplakin-containing regions of the plasma membrane. We conclude that special domains exist in these two IF proteins that are involved in binding to the desmosomal plaque. Previous ArticleNext Article Volume 2Issue 51 May 1983In this issue RelatedDetailsLoading ..." @default.
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• W177060896 date "1983-05-01" @default.
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• W177060896 title "Specific attachment of desmin filaments to desmosomal plaques in cardiac myocytes." @default.
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• W177060896 doi "https://doi.org/10.1002/j.1460-2075.1983.tb01493.x" @default.
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