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- W1770647645 abstract "In adult sheep, cadmium (Cd) accumulates in both liver and kidney tissue in an age dependant manner. To quantify the accumulation of Cd in the developing foetus and investigate the relationship with the Cd status of the maternal parent, liver and kidney samples were collected from both Romney and Merino foetuses, approximately fortnightly, from 60 days after conception up to parturition, and from the suckling lamb, weekly over three weeks. Matching liver and kidney samples were also obtained from the dam. Tissue sub-samples were analysed for Cd by Zeeman electrothermal atomic absorption and for zinc (Zn) by plasma emission spectrometry. The same tissues were also analysed for metallothionein-mRNA by dot blot hybridisation of total RNA extracts to assist in identifying regulatory aspects of Cd accumulation in hepatic foetal tissue and any relationship with Zn. Cadmium concentrations (means f s.e.; ng Cd/g Fw) in pre-parturition and neonate Romney lamb liver (kidney) tissue compared with those in the adult were: 1.1iO.1(2.5~tO.25), 2.4fo.4 (2.8fo.4) and 1391t8 (1208i99) respectively. Merino tissue Cd concentrations were similar to those in the Romney. Although 2% concentrations in liver tissue from the developing foetus decreased with increasing gestation time, Cd concentrations remained low and relatively constant over this period, but increased markedly after parturition. There was no cowlation between Cd in tissue from the dam and that of the progeny and the data indicate that although placental transfer of Cd is minor, a small influx of Cd from the dam into the foetal liver occurs concomitantly with a much larger flux of Zn into the developing liver between 110 and 130 days after conception. Both Cd and Zn concentrations in foetal and adult liver and kidney tissue were correlated with MT mRNA." @default.
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- W1770647645 date "1995-01-01" @default.
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- W1770647645 title "Metabolic changes of cadmium and zinc in kidney and liver tissue during foetal development in Romney and Merino sheep" @default.
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