Matches in SemOpenAlex for { <https://semopenalex.org/work/W177066709> ?p ?o ?g. }
Showing items 1 to 87 of
87
with 100 items per page.
- W177066709 endingPage "72" @default.
- W177066709 startingPage "465" @default.
- W177066709 abstract "Sorted OKT4+ cells treated with pokeweed mitogen (PWM) and subsequently X-irradiated were used as a source of helper T cells to examine human T and B cell function. PWM-induced immunoprotein synthesis by human peripheral blood lymphocytes was the model used to study the cellular interactions. PWM was shown to induce helper T cell function which caused non-PWM treated B cells to secrete immunoglobulin. PBL from certain individuals could not be induced by PWM to secrete Ig therefore allogeneic co-cultures of helper T cells and B cells were examined to define the defective cell population. Ig synthesis in allogeneic cultures of T and B cells was always greater than that observed in autologous cultures when cells from responders were assayed. However, when allogeneic cultures were initiated using B cells from a responder and PWM treated T cells from a non-responder and examined for Ig synthesis, the B cell responses were markedly lower than seen in the autologous responder cultures. In addition, PWM activated helper T cells from a responder induced a significantly higher Ig synthesis by B cells from a non-responder. These observations indicate that PBL from individuals who do not respond in a PWM driven Ig synthesis assay have relatively normal B cell function but are deficient in helper T cell function." @default.
- W177066709 created "2016-06-24" @default.
- W177066709 creator A5000291239 @default.
- W177066709 creator A5005958647 @default.
- W177066709 creator A5009124434 @default.
- W177066709 creator A5088546364 @default.
- W177066709 date "1983-08-01" @default.
- W177066709 modified "2023-09-27" @default.
- W177066709 title "Human B cell function in responder and non-responder individuals. II. The role of T helper cells in promoting the PWM-induced B cell production of immunoprotein." @default.
- W177066709 cites W1494779975 @default.
- W177066709 cites W1498874223 @default.
- W177066709 cites W1506015065 @default.
- W177066709 cites W1541103016 @default.
- W177066709 cites W1545572267 @default.
- W177066709 cites W1571911874 @default.
- W177066709 cites W1607369399 @default.
- W177066709 cites W1974957197 @default.
- W177066709 cites W2006378614 @default.
- W177066709 cites W2026972892 @default.
- W177066709 cites W2040600292 @default.
- W177066709 cites W2060248408 @default.
- W177066709 cites W2062028486 @default.
- W177066709 cites W2076749285 @default.
- W177066709 cites W2077173353 @default.
- W177066709 cites W2111471472 @default.
- W177066709 cites W2132295926 @default.
- W177066709 cites W2145647503 @default.
- W177066709 cites W2160274453 @default.
- W177066709 cites W2160952645 @default.
- W177066709 cites W2329211716 @default.
- W177066709 cites W2417399329 @default.
- W177066709 cites W246028644 @default.
- W177066709 cites W2615281328 @default.
- W177066709 cites W58776773 @default.
- W177066709 cites W2116347 @default.
- W177066709 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1535677" @default.
- W177066709 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6224612" @default.
- W177066709 hasPublicationYear "1983" @default.
- W177066709 type Work @default.
- W177066709 sameAs 177066709 @default.
- W177066709 citedByCount "4" @default.
- W177066709 crossrefType "journal-article" @default.
- W177066709 hasAuthorship W177066709A5000291239 @default.
- W177066709 hasAuthorship W177066709A5005958647 @default.
- W177066709 hasAuthorship W177066709A5009124434 @default.
- W177066709 hasAuthorship W177066709A5088546364 @default.
- W177066709 hasConcept C137061746 @default.
- W177066709 hasConcept C159654299 @default.
- W177066709 hasConcept C202751555 @default.
- W177066709 hasConcept C203014093 @default.
- W177066709 hasConcept C2776090121 @default.
- W177066709 hasConcept C2778453870 @default.
- W177066709 hasConcept C2781005381 @default.
- W177066709 hasConcept C55493867 @default.
- W177066709 hasConcept C86803240 @default.
- W177066709 hasConcept C8891405 @default.
- W177066709 hasConceptScore W177066709C137061746 @default.
- W177066709 hasConceptScore W177066709C159654299 @default.
- W177066709 hasConceptScore W177066709C202751555 @default.
- W177066709 hasConceptScore W177066709C203014093 @default.
- W177066709 hasConceptScore W177066709C2776090121 @default.
- W177066709 hasConceptScore W177066709C2778453870 @default.
- W177066709 hasConceptScore W177066709C2781005381 @default.
- W177066709 hasConceptScore W177066709C55493867 @default.
- W177066709 hasConceptScore W177066709C86803240 @default.
- W177066709 hasConceptScore W177066709C8891405 @default.
- W177066709 hasIssue "2" @default.
- W177066709 hasLocation W1770667091 @default.
- W177066709 hasOpenAccess W177066709 @default.
- W177066709 hasPrimaryLocation W1770667091 @default.
- W177066709 hasRelatedWork W128451109 @default.
- W177066709 hasRelatedWork W1483613960 @default.
- W177066709 hasRelatedWork W1564867503 @default.
- W177066709 hasRelatedWork W1982465805 @default.
- W177066709 hasRelatedWork W2054543661 @default.
- W177066709 hasRelatedWork W2070137130 @default.
- W177066709 hasRelatedWork W2072545085 @default.
- W177066709 hasRelatedWork W2414328232 @default.
- W177066709 hasRelatedWork W2615281328 @default.
- W177066709 hasRelatedWork W3139301998 @default.
- W177066709 hasVolume "53" @default.
- W177066709 isParatext "false" @default.
- W177066709 isRetracted "false" @default.
- W177066709 magId "177066709" @default.
- W177066709 workType "article" @default.