FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W17708317> ?p ?o ?g. }

• W17708317 abstract "Colony-stimulating factors (CSFs) are pivotal for proliferation and function of hematopoietic cells. We found that lymphotoxin, a product of activated lymphocytes, stimulates accumulation of granulocyte- macrophage (GM)-CSF and macrophage (M)-CSF proteins and mRNAs in fibroblasts. An increase in GM- and M-CSF mRNA levels occurred within 2 hours after addition of 1,000 U/mL lymphotoxin and levels plateaued over the next 24 hours. Tumor necrosis factor alpha (TNF alpha) was about five times more potent than lymphotoxin at low concentrations, and was nearly 1.5 to to 2 times more potent at maximally stimulating concentrations of the cytokines. Stimulation by lymphotoxin did not require either new protein synthesis or protein kinase-C stimulation. Stability studies of GM- and M-CSF transcripts in fibroblasts showed that M-CSF mRNA was five times more stable (half-life [t 1/2], 100 minutes) than GM-CSF mRNA (t 1/2, 20 minutes). Stability of these mRNAs was unchanged after stimulation of the cells with lymphotoxin. In addition, exposure of cells to 12-O-tetradecanoylphorbol 13-acetate did not alter stability of M-CSF mRNA but markedly prolonged the stability of GM-CSF mRNA. This is consistent with data showing that the AT-rich consensus region in the 3′ untranslated region of many transiently expressed cytokines including GM-CSF but not M-CSF, play a major role in their mRNA stability. Our results suggest that activated lymphocytes can affect hematopoietic cell function and growth by stimulating production of CSFs by mesenchymal cells." @default.
• W17708317 created "2016-06-24" @default.
• W17708317 creator A5015956479 @default.
• W17708317 creator A5028290908 @default.
• W17708317 creator A5082903377 @default.
• W17708317 date "1989-11-15" @default.
• W17708317 modified "2023-09-27" @default.
• W17708317 title "Lymphotoxin: stimulation and regulation of colony-stimulating factors in fibroblasts" @default.
• W17708317 cites W1481451080 @default.
• W17708317 cites W1502681603 @default.
• W17708317 cites W1524769916 @default.
• W17708317 cites W1556400906 @default.
• W17708317 cites W1556829890 @default.
• W17708317 cites W1567377967 @default.
• W17708317 cites W1589218234 @default.
• W17708317 cites W1591901485 @default.
• W17708317 cites W1594758412 @default.
• W17708317 cites W1602113709 @default.
• W17708317 cites W1602891624 @default.
• W17708317 cites W1796692482 @default.
• W17708317 cites W1909940207 @default.
• W17708317 cites W1976415203 @default.
• W17708317 cites W1977157092 @default.
• W17708317 cites W1978310945 @default.
• W17708317 cites W1987331991 @default.
• W17708317 cites W1987722323 @default.
• W17708317 cites W1989783048 @default.
• W17708317 cites W1991367605 @default.
• W17708317 cites W1991569222 @default.
• W17708317 cites W2001692359 @default.
• W17708317 cites W2007673531 @default.
• W17708317 cites W2014669590 @default.
• W17708317 cites W2025732397 @default.
• W17708317 cites W2031750572 @default.
• W17708317 cites W2038891519 @default.
• W17708317 cites W2046477402 @default.
• W17708317 cites W2066804997 @default.
• W17708317 cites W2068224780 @default.
• W17708317 cites W2077044101 @default.
• W17708317 cites W2080532845 @default.
• W17708317 cites W2124503156 @default.
• W17708317 cites W2141001643 @default.
• W17708317 cites W2143576638 @default.
• W17708317 cites W2261081340 @default.
• W17708317 cites W2395321879 @default.
• W17708317 cites W2396279660 @default.
• W17708317 cites W2412270229 @default.
• W17708317 cites W3112356918 @default.
• W17708317 cites W2096120754 @default.
• W17708317 doi "https://doi.org/10.1182/blood.v74.7.2383.bloodjournal7472383" @default.
• W17708317 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2679916" @default.
• W17708317 hasPublicationYear "1989" @default.
• W17708317 type Work @default.
• W17708317 sameAs 17708317 @default.
• W17708317 citedByCount "15" @default.
• W17708317 crossrefType "journal-article" @default.
• W17708317 hasAuthorship W17708317A5015956479 @default.
• W17708317 hasAuthorship W17708317A5028290908 @default.
• W17708317 hasAuthorship W17708317A5082903377 @default.
• W17708317 hasBestOaLocation W177083171 @default.
• W17708317 hasConcept C103813035 @default.
• W17708317 hasConcept C104317684 @default.
• W17708317 hasConcept C105580179 @default.
• W17708317 hasConcept C109159458 @default.
• W17708317 hasConcept C126322002 @default.
• W17708317 hasConcept C134018914 @default.
• W17708317 hasConcept C153911025 @default.
• W17708317 hasConcept C17991360 @default.
• W17708317 hasConcept C203014093 @default.
• W17708317 hasConcept C24998067 @default.
• W17708317 hasConcept C2777478134 @default.
• W17708317 hasConcept C2778690821 @default.
• W17708317 hasConcept C2779958370 @default.
• W17708317 hasConcept C28328180 @default.
• W17708317 hasConcept C54500882 @default.
• W17708317 hasConcept C55493867 @default.
• W17708317 hasConcept C61879462 @default.
• W17708317 hasConcept C71924100 @default.
• W17708317 hasConcept C86803240 @default.
• W17708317 hasConcept C95444343 @default.
• W17708317 hasConceptScore W17708317C103813035 @default.
• W17708317 hasConceptScore W17708317C104317684 @default.
• W17708317 hasConceptScore W17708317C105580179 @default.
• W17708317 hasConceptScore W17708317C109159458 @default.
• W17708317 hasConceptScore W17708317C126322002 @default.
• W17708317 hasConceptScore W17708317C134018914 @default.
• W17708317 hasConceptScore W17708317C153911025 @default.
• W17708317 hasConceptScore W17708317C17991360 @default.
• W17708317 hasConceptScore W17708317C203014093 @default.
• W17708317 hasConceptScore W17708317C24998067 @default.
• W17708317 hasConceptScore W17708317C2777478134 @default.
• W17708317 hasConceptScore W17708317C2778690821 @default.
• W17708317 hasConceptScore W17708317C2779958370 @default.
• W17708317 hasConceptScore W17708317C28328180 @default.
• W17708317 hasConceptScore W17708317C54500882 @default.
• W17708317 hasConceptScore W17708317C55493867 @default.
• W17708317 hasConceptScore W17708317C61879462 @default.
• W17708317 hasConceptScore W17708317C71924100 @default.
• W17708317 hasConceptScore W17708317C86803240 @default.
• W17708317 hasConceptScore W17708317C95444343 @default.

• next