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• W1770976135 abstract "Background and Aim . Leptin has two forms in the circulation: free and bound forms. The soluble leptin receptor (sOB-R) circulates in the blood and can bind to leptin. The aim of this study is to assess the concentrations of the leptin and the sOB-R in PCOS and its relation to adiposity, insulin resistance, and androgens. Methods . A cross-sectional study included 78 female students aged 17–25 years. Fasting serum leptin and sOB-R concentrations were measured. The anthropometric variables and the hormonal profile such as insulin, female and male sex hormones, and prolactin were assessed. Results . In PCOS, leptin level (ng/ml) and free leptin index (FLI) increased significantly while sOB-R (ng/ml) significantly decreased compared to control subjects. In age-matched subjects, obese PCOS had increased leptin level in ng/ml (median level with interquartile levels) of 45.67 (41.98–48.04) and decreased sOB-R in ng/ml 11.47 (7.59–16.44) compared to lean PCOS 16.97 (10.60–45.55) for leptin and 16.62 (11.61–17.96) for sOB-R with<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M1><mml:mrow><mml:mi>p</mml:mi></mml:mrow></mml:math>values 0.013 and 0.042, respectively. However, body mass index (BMI) is significantly correlated with leptin and s-OBR, while no significant correlations with parameters of insulin resistance were detected. Conclusion . PCOS is associated with hyperleptinemia and increased free leptin index. Decreased sOB-R could be a compensatory mechanism for the defective action of leptin." @default.
• W1770976135 created "2016-06-24" @default.
• W1770976135 creator A5021968833 @default.
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• W1770976135 date "2015-01-01" @default.
• W1770976135 modified "2023-10-17" @default.
• W1770976135 title "Leptin as well as Free Leptin Receptor Is Associated with Polycystic Ovary Syndrome in Young Women" @default.
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• W1770976135 doi "https://doi.org/10.1155/2015/927805" @default.
• W1770976135 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4477211" @default.
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