Matches in SemOpenAlex for { <https://semopenalex.org/work/W1771162562> ?p ?o ?g. }
- W1771162562 endingPage "4950" @default.
- W1771162562 startingPage "4940" @default.
- W1771162562 abstract "Abstract Glucocorticoid (GC)-induced leucine zipper (GILZ) has been shown to mediate or mimic several actions of GC. This study assessed the role of GILZ in self-resolving and GC-induced resolution of neutrophilic inflammation induced by LPS in mice. GILZ expression was increased during the resolution phase of LPS-induced pleurisy, especially in macrophages with resolving phenotypes. Pretreating LPS-injected mice with trans-activator of transcription peptide (TAT)–GILZ, a cell-permeable GILZ fusion protein, shortened resolution intervals and improved resolution indices. Therapeutic administration of TAT-GILZ induced inflammation resolution, decreased cytokine levels, and promoted caspase-dependent neutrophil apoptosis. TAT-GILZ also modulated the activation of the survival-controlling proteins ERK1/2, NF-κB and Mcl-1. GILZ deficiency was associated with an early increase of annexin A1 (AnxA1) and did not modify the course of neutrophil influx induced by LPS. Dexamethasone treatment resolved inflammation and induced GILZ expression that was dependent on AnxA1. Dexamethasone-induced resolution was not altered in GILZ−/− mice due to compensatory expression and action of AnxA1. Our results show that therapeutic administration of GILZ efficiently induces a proapoptotic program that promotes resolution of neutrophilic inflammation induced by LPS. Alternatively, a lack of endogenous GILZ during the resolution of inflammation is compensated by AnxA1 overexpression." @default.
- W1771162562 created "2016-06-24" @default.
- W1771162562 creator A5002227135 @default.
- W1771162562 creator A5002720973 @default.
- W1771162562 creator A5010610120 @default.
- W1771162562 creator A5013977089 @default.
- W1771162562 creator A5016216191 @default.
- W1771162562 creator A5022639389 @default.
- W1771162562 creator A5025792373 @default.
- W1771162562 creator A5029441169 @default.
- W1771162562 creator A5031887300 @default.
- W1771162562 creator A5036855659 @default.
- W1771162562 creator A5044815873 @default.
- W1771162562 creator A5046118229 @default.
- W1771162562 creator A5065756562 @default.
- W1771162562 creator A5069985989 @default.
- W1771162562 creator A5073526459 @default.
- W1771162562 creator A5074292351 @default.
- W1771162562 creator A5083823979 @default.
- W1771162562 creator A5085039459 @default.
- W1771162562 date "2015-05-15" @default.
- W1771162562 modified "2023-10-18" @default.
- W1771162562 title "The Role and Effects of Glucocorticoid-Induced Leucine Zipper in the Context of Inflammation Resolution" @default.
- W1771162562 cites W1585536154 @default.
- W1771162562 cites W1599826635 @default.
- W1771162562 cites W1615645448 @default.
- W1771162562 cites W1836416096 @default.
- W1771162562 cites W1858954343 @default.
- W1771162562 cites W1903165832 @default.
- W1771162562 cites W1966198733 @default.
- W1771162562 cites W1968932167 @default.
- W1771162562 cites W1971318332 @default.
- W1771162562 cites W1978543910 @default.
- W1771162562 cites W1986668505 @default.
- W1771162562 cites W1995389009 @default.
- W1771162562 cites W1996740963 @default.
- W1771162562 cites W2007498357 @default.
- W1771162562 cites W2011885150 @default.
- W1771162562 cites W2017916832 @default.
- W1771162562 cites W2023800097 @default.
- W1771162562 cites W2028906750 @default.
- W1771162562 cites W2033644126 @default.
- W1771162562 cites W2035296519 @default.
- W1771162562 cites W2053304088 @default.
- W1771162562 cites W2055723006 @default.
- W1771162562 cites W2055876243 @default.
- W1771162562 cites W2063861465 @default.
- W1771162562 cites W2065769697 @default.
- W1771162562 cites W2066000649 @default.
- W1771162562 cites W2068198033 @default.
- W1771162562 cites W2074171762 @default.
- W1771162562 cites W2076003134 @default.
- W1771162562 cites W2081005510 @default.
- W1771162562 cites W2087669700 @default.
- W1771162562 cites W2088815545 @default.
- W1771162562 cites W2092134437 @default.
- W1771162562 cites W2095345745 @default.
- W1771162562 cites W2102174943 @default.
- W1771162562 cites W2106712145 @default.
- W1771162562 cites W2108426267 @default.
- W1771162562 cites W2112687470 @default.
- W1771162562 cites W2112842079 @default.
- W1771162562 cites W2118189387 @default.
- W1771162562 cites W2120699390 @default.
- W1771162562 cites W2127942675 @default.
- W1771162562 cites W2128864178 @default.
- W1771162562 cites W2141134562 @default.
- W1771162562 cites W2148622539 @default.
- W1771162562 cites W2151868528 @default.
- W1771162562 cites W2160477667 @default.
- W1771162562 cites W2162462917 @default.
- W1771162562 cites W2162569210 @default.
- W1771162562 cites W2164146931 @default.
- W1771162562 doi "https://doi.org/10.4049/jimmunol.1401722" @default.
- W1771162562 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25876761" @default.
- W1771162562 hasPublicationYear "2015" @default.
- W1771162562 type Work @default.
- W1771162562 sameAs 1771162562 @default.
- W1771162562 citedByCount "81" @default.
- W1771162562 countsByYear W17711625622015 @default.
- W1771162562 countsByYear W17711625622016 @default.
- W1771162562 countsByYear W17711625622017 @default.
- W1771162562 countsByYear W17711625622018 @default.
- W1771162562 countsByYear W17711625622019 @default.
- W1771162562 countsByYear W17711625622020 @default.
- W1771162562 countsByYear W17711625622021 @default.
- W1771162562 countsByYear W17711625622022 @default.
- W1771162562 countsByYear W17711625622023 @default.
- W1771162562 crossrefType "journal-article" @default.
- W1771162562 hasAuthorship W1771162562A5002227135 @default.
- W1771162562 hasAuthorship W1771162562A5002720973 @default.
- W1771162562 hasAuthorship W1771162562A5010610120 @default.
- W1771162562 hasAuthorship W1771162562A5013977089 @default.
- W1771162562 hasAuthorship W1771162562A5016216191 @default.
- W1771162562 hasAuthorship W1771162562A5022639389 @default.
- W1771162562 hasAuthorship W1771162562A5025792373 @default.
- W1771162562 hasAuthorship W1771162562A5029441169 @default.
- W1771162562 hasAuthorship W1771162562A5031887300 @default.