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• W1771585733 abstract "Introduction The ability of even the most complex protein molecules to fold to their biologically functional states is perhaps the most fundamental example of biological self-assembly, one of the defining characteristics of living systems (Vendruscolo et al ., 2003). The process of protein folding in the cellular environment can, in principle, begin whilst the nascent chain is still attached to the ribosome, and there is clear evidence that some proteins do fold at least partially in such a co-translational manner (Hardesty and Kramer, 2001). Other proteins are known to undergo the major part of their folding only after release from the ribosome, whilst yet others fold in specific cellular compartments such as the endoplasmic reticulum (ER) or mitochondria following translocation through membranes (Hartl and Hayer-Hartl, 2002). Although the fundamental principles underlying the mechanism of folding are unlikely to differ in any significant manner from those elucidated from in vitro studies, many details of the way in which individual proteins fold will undoubtedly depend on the environment in which they are located. In particular, as incompletely folded chains inevitably expose to the outside world many regions of the polypeptide molecule that are buried in the native state, such species are prone to inappropriate interactions with other molecules within the complex and crowded cellular environment. Such interactions can result both in the disruption of normal cellular processes and in self-association or aggregation." @default.
• W1771585733 created "2016-06-24" @default.
• W1771585733 creator A5091898546 @default.
• W1771585733 date "2007-08-02" @default.
• W1771585733 modified "2023-09-26" @default.
• W1771585733 title "Diseases of protein misfolding" @default.
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• W1771585733 doi "https://doi.org/10.1017/cbo9780511543555.008" @default.
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