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- W1771768357 abstract "284 Objectives Adenine nucleotide translocase (ANT) plays an essential role in cellular energy metabolism. ANT2, which is linked to the rate of glycolytic metabolism, is an important indicator of carcinogenesis. However, it has not been reported yet on correlation of ANT2 expression and 18F-FDG uptake. Therefore we investigate relationship between 18F-FDG tumor uptake and ANT2 expression in thyroid carcinomas. Methods We examined ANT2 mRNA expression of thyroid carcinoma cell lines (papillary (TPC-1), anaplastic (FRO)) and normal (N-thy-ori3.1) thyroid cell line using reverse transcriptase PCR. 18F-FDG uptakes were evaluated in thyroid cell lines and in FRO cells ANT2-downregulated by ANT shRNA. Furthermore, 18F-FDG positron emission tomography (PET) was performed in FRO tumor-bearing mice inoculated with scramble and ANT2 shRNA (50 ug / 50 ul) intratumorally. Results ANT2 mRNA expression in FRO cells was higher (74-fold) than those in TPC-1 and N-thy-ori3.1. 18F-FDG uptake in FRO cells (3-fold) were higher than N-thy-ori3.1. 18F-FDG uptake was reduced by 40% in FRO cells transfected with ANT2 shRNA. In mouse model, 18F-FDG tumor uptake with ANT2 shRNA was reduced by 30%. Conclusions We demonstrated that ANT2 expression correlated to improved 18F-FDG uptake in thyroid anaplastic carcinoma. We suggest that evaluation of ANT2 expression with 18F-FDG PET scan could be needed as a diagnostic marker of thyroid anaplastic carcinoma." @default.
- W1771768357 created "2016-06-24" @default.
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- W1771768357 date "2014-05-01" @default.
- W1771768357 modified "2023-09-28" @default.
- W1771768357 title "Adenine nucleotide translocase 2 associates with increased 18F-FDG PET uptake in thyroid anaplastic carcinoma" @default.
- W1771768357 hasPublicationYear "2014" @default.
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