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- W1771781168 abstract "2-(3′,5′-Difluorophenyl)-3-(4′-methylsulfonylphenyl)cyclopent-2-enone (1) displays high selectivity and potency against COX-2. Three efficient syntheses of this diarylcyclopentenone are described. The first approach employs a Suzuki coupling reaction as the key step while the second synthesis features an intramolecular Friedel-Crafts acylation. The third, and preferred route to this compound involves a sequential malonate alkylation and acylation and ring-closure sequence." @default.
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- W1771781168 date "1999-05-01" @default.
- W1771781168 modified "2023-09-27" @default.
- W1771781168 title "Efficient syntheses of 2-(3′,5′-difluorophenyl)-3-(4′-methylsulfonylphenyl)cyclopent-2-enone, a potent COX-2 inhibitor" @default.
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- W1771781168 doi "https://doi.org/10.1016/s0040-4020(99)00274-4" @default.
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