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• W1772299815 endingPage "300" @default.
• W1772299815 startingPage "257" @default.
• W1772299815 abstract "Publisher Summary This chapter reviews pertinent studies employing genetically modified animals that address liver growth regulation and neoplasia. The most common method of producing genetically altered animals is to introduce DNA into fertilized mouse eggs. This process gives rise to transgenic mice that have incorporated the foreign DNA into their genome. To accomplish this, fertilized one-cell mouse eggs in egg culture medium are fixed in place on the stage of a microscope and pierced by a sharp-tipped microinjection needle containing a DNA solution. The solution is expelled into one of the two egg pronuclei, and surviving eggs are surgically transferred into the oviducts of pseudopregnant foster mothers. Offspring resulting from this procedure are screened to identify those in which the foreign DNA (transgene) has become integrated into the genome; these mice should carry a copy of the transgene in every cell of the body. With this methodology, experimental design is critically dependent on the nature of the transgene DNA. Transgene constructs generally contain two functional elements: the DNA sequence encoding the protein whose activity is being studied and the DNA regulatory elements (enhancer/promoters) that target gene expression specifically to one or more cell types. Thus, chimeric genes contain a novel combination of regulatory and coding elements and can target gene expression to novel tissues. To date, transgenic mice have provided the principal models of genetically altered animals employed in the studies of liver growth regulation and carcinogenesis." @default.
• W1772299815 created "2016-06-24" @default.
• W1772299815 creator A5039963746 @default.
• W1772299815 date "1995-01-01" @default.
• W1772299815 modified "2023-09-25" @default.
• W1772299815 title "Transgenic models of hepatic growth regulation and hepatocarcinogenesis" @default.
• W1772299815 cites W1026594691 @default.
• W1772299815 cites W134035541 @default.
• W1772299815 cites W136054260 @default.
• W1772299815 cites W1483694031 @default.
• W1772299815 cites W1496000702 @default.
• W1772299815 cites W149877699 @default.
• W1772299815 cites W1499782463 @default.
• W1772299815 cites W1502496330 @default.
• W1772299815 cites W1509107903 @default.
• W1772299815 cites W1509867470 @default.
• W1772299815 cites W1544473294 @default.
• W1772299815 cites W1548594910 @default.
• W1772299815 cites W1553229669 @default.
• W1772299815 cites W1563828822 @default.
• W1772299815 cites W1567771113 @default.
• W1772299815 cites W1583012584 @default.
• W1772299815 cites W1598192081 @default.
• W1772299815 cites W1598477767 @default.
• W1772299815 cites W1600331093 @default.
• W1772299815 cites W1608357724 @default.
• W1772299815 cites W1792201981 @default.
• W1772299815 cites W1794576275 @default.
• W1772299815 cites W1885980745 @default.
• W1772299815 cites W1902638906 @default.
• W1772299815 cites W1944408100 @default.
• W1772299815 cites W1951553828 @default.
• W1772299815 cites W1964288182 @default.
• W1772299815 cites W1964313992 @default.
• W1772299815 cites W1964915980 @default.
• W1772299815 cites W1965351187 @default.
• W1772299815 cites W1966737159 @default.
• W1772299815 cites W1968458490 @default.
• W1772299815 cites W1968550008 @default.
• W1772299815 cites W1969680369 @default.
• W1772299815 cites W1970010452 @default.
• W1772299815 cites W1971695712 @default.
• W1772299815 cites W1972036696 @default.
• W1772299815 cites W1975279384 @default.
• W1772299815 cites W197557636 @default.
• W1772299815 cites W1978218804 @default.
• W1772299815 cites W1979027806 @default.
• W1772299815 cites W1980430393 @default.
• W1772299815 cites W1982882974 @default.
• W1772299815 cites W1985423447 @default.
• W1772299815 cites W1986150533 @default.
• W1772299815 cites W1986826730 @default.
• W1772299815 cites W1991355519 @default.
• W1772299815 cites W1992256486 @default.
• W1772299815 cites W1993395866 @default.
• W1772299815 cites W1993785975 @default.
• W1772299815 cites W1994926199 @default.
• W1772299815 cites W1995289527 @default.
• W1772299815 cites W1996545524 @default.
• W1772299815 cites W2000101394 @default.
• W1772299815 cites W2002085824 @default.
• W1772299815 cites W2002886319 @default.
• W1772299815 cites W2004811543 @default.
• W1772299815 cites W2005153644 @default.
• W1772299815 cites W2005778374 @default.
• W1772299815 cites W2006298792 @default.
• W1772299815 cites W2007706733 @default.
• W1772299815 cites W2013195094 @default.
• W1772299815 cites W2014897341 @default.
• W1772299815 cites W2015615089 @default.
• W1772299815 cites W2018349527 @default.
• W1772299815 cites W2020022390 @default.
• W1772299815 cites W2021699860 @default.
• W1772299815 cites W2022527563 @default.
• W1772299815 cites W2024191382 @default.
• W1772299815 cites W2028602466 @default.
• W1772299815 cites W2031121245 @default.
• W1772299815 cites W2035560052 @default.
• W1772299815 cites W2036314039 @default.
• W1772299815 cites W2036452487 @default.
• W1772299815 cites W2038745712 @default.
• W1772299815 cites W2039713619 @default.
• W1772299815 cites W2041138123 @default.
• W1772299815 cites W2043499239 @default.
• W1772299815 cites W2044244799 @default.
• W1772299815 cites W2048139403 @default.
• W1772299815 cites W2048536123 @default.
• W1772299815 cites W2049395473 @default.
• W1772299815 cites W2051153807 @default.
• W1772299815 cites W2053275898 @default.
• W1772299815 cites W2061353549 @default.
• W1772299815 cites W2061756590 @default.
• W1772299815 cites W2062646175 @default.
• W1772299815 cites W2063033265 @default.
• W1772299815 cites W2063810681 @default.
• W1772299815 cites W2065519715 @default.
• W1772299815 cites W2068609509 @default.
• W1772299815 cites W2068764558 @default.

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