FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1772586054> ?p ?o ?g. }

• W1772586054 abstract "ABSTRACT Aim: Blood-based specimens may be a potential source of non-invasive DNA methylation cancer biomarkers. Peripheral blood leukocytes from patients with solid tumors exhibit complex and distinct cancer-associated DNA methylation patterns, which might be seen as epigenetic biomarkers with significant clinical potential. However, peripheral blood cell methylation profiles are largely unknown in hematopoietic cancers. Our aim was to compare DNA methylation status in bone marrow (BM) aspirate and peripheral blood (PB) of Myelodysplastic Syndrome (MDS) patients at diagnosis. Methods: We compare DNA methylation status of the tumor suppressor genes, p15, p16, p53, DAPK and MGMT, and of TRAIL (TNF-Related Apoptotic Inducing Ligand) receptor genes, TRAIL-DcR1, -DcR2, -DR4 and -DR5), in 45 Myelodysplastic Syndrome (MDS) patients at diagnosis, in genomic DNA obtained from BM aspirate and PB samples, after informed consent. Genomic DNA was isolated by standard protocols and modified by sodium bissulphite. The MS-PCR for each gene was performed using two sets of primers, one for methylated DNA and other for unmethylated DNA. k2 Test was used to analyses association between groups and Kappa statistics to evaluate concordance, results were considered statistically significant when p Results: We observed a good concordant results between BM and PB samples in 77,8% of patients for p16 (p = 0,017), 75,6% for p15 (p = 0,028), 62,2% for DAPK (p = 0,031), 84,4% for TRAIL-DcR1, 68,9% for TRAIL-DcR2, 66,7% for TRAIL-DR4 and a discordant results for TRAIL-DR5 gene (p = 0,012), since only 37,8% of the tested samples were concordant. In some cases discrepancies were also bidirectional, with cases presenting demethylated PB and methylated BM aspirate and vice versa. No patient presented p53 and MGMT gene methylated. Conclusions: Our results show a correlation between gene methylation patterns in PB and BM aspirate in MDS patients. Although DNA methylation patterns measured in PB may have great potential as informative biomarkers of cancer risk and prognosis, large systematic and prospective studies will be needed. Disclosure: All authors have declared no conflicts of interest." @default.
• W1772586054 created "2016-06-24" @default.
• W1772586054 creator A5001951100 @default.
• W1772586054 creator A5003676516 @default.
• W1772586054 creator A5008946581 @default.
• W1772586054 creator A5016566105 @default.
• W1772586054 creator A5022726069 @default.
• W1772586054 creator A5032971294 @default.
• W1772586054 creator A5044343447 @default.
• W1772586054 creator A5051474127 @default.
• W1772586054 creator A5057333936 @default.
• W1772586054 creator A5071260237 @default.
• W1772586054 creator A5072779490 @default.
• W1772586054 creator A5074589429 @default.
• W1772586054 creator A5079565241 @default.
• W1772586054 creator A5080765031 @default.
• W1772586054 creator A5085448497 @default.
• W1772586054 creator A5091908333 @default.
• W1772586054 date "2014-09-01" @default.
• W1772586054 modified "2023-10-17" @default.
• W1772586054 title "Gene Methylation in Myelodysplastic Syndrome – a Comparative Study Between Bone Marrow and Peripheral Blood" @default.
• W1772586054 doi "https://doi.org/10.1093/annonc/mdu339.32" @default.
• W1772586054 hasPublicationYear "2014" @default.
• W1772586054 type Work @default.
• W1772586054 sameAs 1772586054 @default.
• W1772586054 citedByCount "0" @default.
• W1772586054 crossrefType "journal-article" @default.
• W1772586054 hasAuthorship W1772586054A5001951100 @default.
• W1772586054 hasAuthorship W1772586054A5003676516 @default.
• W1772586054 hasAuthorship W1772586054A5008946581 @default.
• W1772586054 hasAuthorship W1772586054A5016566105 @default.
• W1772586054 hasAuthorship W1772586054A5022726069 @default.
• W1772586054 hasAuthorship W1772586054A5032971294 @default.
• W1772586054 hasAuthorship W1772586054A5044343447 @default.
• W1772586054 hasAuthorship W1772586054A5051474127 @default.
• W1772586054 hasAuthorship W1772586054A5057333936 @default.
• W1772586054 hasAuthorship W1772586054A5071260237 @default.
• W1772586054 hasAuthorship W1772586054A5072779490 @default.
• W1772586054 hasAuthorship W1772586054A5074589429 @default.
• W1772586054 hasAuthorship W1772586054A5079565241 @default.
• W1772586054 hasAuthorship W1772586054A5080765031 @default.
• W1772586054 hasAuthorship W1772586054A5085448497 @default.
• W1772586054 hasAuthorship W1772586054A5091908333 @default.
• W1772586054 hasBestOaLocation W17725860541 @default.
• W1772586054 hasConcept C104317684 @default.
• W1772586054 hasConcept C121608353 @default.
• W1772586054 hasConcept C126322002 @default.
• W1772586054 hasConcept C142724271 @default.
• W1772586054 hasConcept C143998085 @default.
• W1772586054 hasConcept C150194340 @default.
• W1772586054 hasConcept C153911025 @default.
• W1772586054 hasConcept C160798450 @default.
• W1772586054 hasConcept C190727270 @default.
• W1772586054 hasConcept C203014093 @default.
• W1772586054 hasConcept C2780007613 @default.
• W1772586054 hasConcept C2780817109 @default.
• W1772586054 hasConcept C3017910909 @default.
• W1772586054 hasConcept C33288867 @default.
• W1772586054 hasConcept C41091548 @default.
• W1772586054 hasConcept C502942594 @default.
• W1772586054 hasConcept C54355233 @default.
• W1772586054 hasConcept C71924100 @default.
• W1772586054 hasConcept C86803240 @default.
• W1772586054 hasConceptScore W1772586054C104317684 @default.
• W1772586054 hasConceptScore W1772586054C121608353 @default.
• W1772586054 hasConceptScore W1772586054C126322002 @default.
• W1772586054 hasConceptScore W1772586054C142724271 @default.
• W1772586054 hasConceptScore W1772586054C143998085 @default.
• W1772586054 hasConceptScore W1772586054C150194340 @default.
• W1772586054 hasConceptScore W1772586054C153911025 @default.
• W1772586054 hasConceptScore W1772586054C160798450 @default.
• W1772586054 hasConceptScore W1772586054C190727270 @default.
• W1772586054 hasConceptScore W1772586054C203014093 @default.
• W1772586054 hasConceptScore W1772586054C2780007613 @default.
• W1772586054 hasConceptScore W1772586054C2780817109 @default.
• W1772586054 hasConceptScore W1772586054C3017910909 @default.
• W1772586054 hasConceptScore W1772586054C33288867 @default.
• W1772586054 hasConceptScore W1772586054C41091548 @default.
• W1772586054 hasConceptScore W1772586054C502942594 @default.
• W1772586054 hasConceptScore W1772586054C54355233 @default.
• W1772586054 hasConceptScore W1772586054C71924100 @default.
• W1772586054 hasConceptScore W1772586054C86803240 @default.
• W1772586054 hasLocation W17725860541 @default.
• W1772586054 hasOpenAccess W1772586054 @default.
• W1772586054 hasPrimaryLocation W17725860541 @default.
• W1772586054 hasRelatedWork W1981258138 @default.
• W1772586054 hasRelatedWork W1986554125 @default.
• W1772586054 hasRelatedWork W1995844463 @default.
• W1772586054 hasRelatedWork W2024722822 @default.
• W1772586054 hasRelatedWork W2025828160 @default.
• W1772586054 hasRelatedWork W2037174835 @default.
• W1772586054 hasRelatedWork W2063927538 @default.
• W1772586054 hasRelatedWork W2074167501 @default.
• W1772586054 hasRelatedWork W2086460900 @default.
• W1772586054 hasRelatedWork W2089528445 @default.
• W1772586054 hasRelatedWork W2124411673 @default.
• W1772586054 hasRelatedWork W2162347903 @default.
• W1772586054 hasRelatedWork W2296563148 @default.
• W1772586054 hasRelatedWork W2389531624 @default.
• W1772586054 hasRelatedWork W2514915762 @default.

• next