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- W1772887165 abstract "19093 Background: Although not an AIDS-defining malignancy, lung cancer is seen in excess in HIV positive patient populations for unclear reasons. The clinical and pathological characteristics of this patient population is poorly understood. Methods: We present a retrospective case series of individuals with known HIV infection who were diagnosed with lung cancers at the Albert Einstein Cancer Center during the post-HAART era (1996–2007). Patients (pts) were identified by treating physicians. Results: A total of 40 individuals (23 M/17 F) with HIV infection and a pathological diagnosis of lung cancer (37 non-small cell/3 small cell) were identified; all but 3 pts were smokers. The median (range) age of pts at diagnosis was 51 (38–74), CD4 count was 213/μL (9–990), median HIV viral load was 422 copies/mL (<40–134,000); 29 pts (72%) had known history of HAART exposure. Of 37 pts with a diagnosis of non-small cell lung cancer, 16 had adenocarcinoma, 7 had squamous pathology, 1 had large cell carcinoma; the pathological type was not specified/poorly differentiated in 13 pts. The stage at diagnosis was I in 7 pts (19%), II in 1 pt (3%), III in 8 pts (22%), and IV in 21 pts (57%). Six of 8 pts with early stage (I/II) disease had surgical intervention; the median (range) CD4 count of these pts at the time of surgery was 180/μL (23–341), and the survival of these pts was 120, 72, 54, 52, 33+ and 1+ months. The median survival of pts with stage III/IV disease was 5 months. Conclusions: This cohort of HIV-infected individuals diagnosed with lung cancer in the post-HAART era includes young smokers, both male and female, with a moderate degree of immunosuppression. Histopathological type and stage of cancer at presentation appear to be similar to immunocompetent individuals. While most pts present with advanced disease and have poor outcomes, survival of patients with early stage disease treated with surgical resection is high. The high frequency of HAART exposure and implied clinical contact with physicians prior to lung cancer diagnosis suggest opportunities for screening and tobacco cessation programs and to increase lung cancer awareness among physicians caring for HIV positive patient populations. No significant financial relationships to disclose." @default.
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- W1772887165 date "2008-05-20" @default.
- W1772887165 modified "2023-10-18" @default.
- W1772887165 title "Lung cancer in HIV infection: A case series" @default.
- W1772887165 doi "https://doi.org/10.1200/jco.2008.26.15_suppl.19093" @default.
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