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- W177297558 abstract "Aim Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is the standard therapy for the treatment of malignant blood diseases or immune system disorders. HLA compatibility influences the transplant outcome and minimizes the risks of rejection or severe graft-versus-host disease. The identification of a compatible unrelated donor depends on the race/ethnicity due to heterogeneity within the various ethnic groups and the high polymorphism of HLA genes that limits the possibility of HSCT from unrelated donors. In Italy, the Italian Bone Marrow Registry (IBMDR) is the main source of unrelated volunteer donors. Here, we report our experience of HLA typing laboratory. Methods The current Italian guidelines include high resolution HLA typing at A, B, C, and DRB1 loci for volunteer unrelated donors in the enrollment time. In 2013, at the Regional Reference Laboratory of Transplant Immunology of Naples (Italy), the donors were typed by sequence specific primers PCR. Results We have identified the HLA-A∗23:18 allele in two different volunteer donors. This is a rare allele in the Italian and Caucasian population (IMGT/HLA AccNo:HLA03170). The allele A∗23:18, for the first time, was identified by SBT in a patient attending HSCT in Italy. To date, this allele is still listed as rare allele in the NMDP rare allele list file version 3.9.0. The HLA typing of these two donors is A∗03:01,∗23:18; B∗07:02,∗14:02; C∗07:02,∗08:02; DRB1∗01:02,∗15:01 and A∗02:05,∗23:18; B∗14:02; C∗08:02; DRB1∗01:02. These donors share the HLA-A∗23:18; B∗14:02; C∗08:02 and DRB1∗01:02 alleles with the patient where this allele was identified for the first time. Both donors are Italians and resident in our region since several generations. Conclusion The high polymorphism and the pattern of HLA alleles and haplotypes distribution in human populations in the world make it difficult to find compatible stem cell donors. However, the role of HLA compatibility at allelic level in allo-HSCT is still debated, especially if mismatches are not localized in exon 2 and 3 of HLA class I genes. Our results highlight that some alleles, considered rare, may be frequent alleles in some regions and therefore it is necessary a more accurate knowledge of allele and haplotype frequencies in order to develop new strategies for the search of HSCT unrelated donors." @default.
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- W177297558 date "2014-10-01" @default.
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- W177297558 title "P133" @default.
- W177297558 doi "https://doi.org/10.1016/j.humimm.2014.08.195" @default.
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