FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1773104009> ?p ?o ?g. }

• W1773104009 endingPage "3959" @default.
• W1773104009 startingPage "3946" @default.
• W1773104009 abstract "ABSTRACT Group IV polysaccharide capsules are common in enteric bacteria and have more recently been described in nontyphoidal Salmonella species. Such capsules are known as O-antigen (O-Ag) capsules, due to their high degree of similarity to the O-Ag of the lipopolysaccharide (LPS O-Ag ). Capsular polysaccharides are known virulence factors of many bacterial pathogens, facilitating evasion of immune recognition and systemic dissemination within the host. Previous studies on the O-Ag capsule of salmonellae have focused primarily on its role in bacterial surface attachment and chronic infection; however, the potential effects of the O-Ag capsule on acute pathogenesis have yet to be investigated. While much of the in vivo innate immune resistance of Salmonella enterica serovar Typhimurium is attributed to the high-molecular-weight LPS, we hypothesized that the O-Ag capsule may enhance this resistance by diminishing surface expression of pathogen-associated molecular patterns, such as flagella, and increasing resistance to host immune molecules. To test this hypothesis, O-Ag capsule-deficient mutants were constructed, and the loss of O-Ag capsular surface expression was confirmed through microscopy and immunoblotting. Loss of O-Ag capsule production did not alter bacterial growth or production of LPS. Western blot analysis and confocal microscopy revealed that O-Ag capsule-deficient mutants demonstrate reduced resistance to killing by human serum. Furthermore, O-Ag capsule-deficient mutants produced exclusively phase I flagellin (FliC). Although O-Ag capsule-deficient mutants did not exhibit reduced virulence in a murine model of acute infection, in vitro results indicate that the O-Ag capsule may function to modify the antigenic nature of the bacterial surface, warranting additional investigation of a potential role of the structure in pathogenesis." @default.
• W1773104009 created "2016-06-24" @default.
• W1773104009 creator A5043254243 @default.
• W1773104009 creator A5082003915 @default.
• W1773104009 date "2015-10-01" @default.
• W1773104009 modified "2023-09-23" @default.
• W1773104009 title "The O-Antigen Capsule of Salmonella enterica Serovar Typhimurium Facilitates Serum Resistance and Surface Expression of FliC" @default.
• W1773104009 cites W1561667804 @default.
• W1773104009 cites W1586139580 @default.
• W1773104009 cites W1918000672 @default.
• W1773104009 cites W1966838487 @default.
• W1773104009 cites W1968834637 @default.
• W1773104009 cites W1969699737 @default.
• W1773104009 cites W1976847457 @default.
• W1773104009 cites W1985782125 @default.
• W1773104009 cites W1989415742 @default.
• W1773104009 cites W1992140057 @default.
• W1773104009 cites W1996212791 @default.
• W1773104009 cites W2003602243 @default.
• W1773104009 cites W2006222978 @default.
• W1773104009 cites W2011258278 @default.
• W1773104009 cites W2017531592 @default.
• W1773104009 cites W2026546359 @default.
• W1773104009 cites W2030337551 @default.
• W1773104009 cites W2031297410 @default.
• W1773104009 cites W2038800520 @default.
• W1773104009 cites W2045265859 @default.
• W1773104009 cites W2054941036 @default.
• W1773104009 cites W2056638087 @default.
• W1773104009 cites W2058270907 @default.
• W1773104009 cites W2063222819 @default.
• W1773104009 cites W2063260972 @default.
• W1773104009 cites W2069502810 @default.
• W1773104009 cites W2074012369 @default.
• W1773104009 cites W2077189992 @default.
• W1773104009 cites W2079593650 @default.
• W1773104009 cites W2097888283 @default.
• W1773104009 cites W2101058428 @default.
• W1773104009 cites W2101997581 @default.
• W1773104009 cites W2104485620 @default.
• W1773104009 cites W2105679191 @default.
• W1773104009 cites W2106079980 @default.
• W1773104009 cites W2106564977 @default.
• W1773104009 cites W2108052469 @default.
• W1773104009 cites W2108209554 @default.
• W1773104009 cites W2110085694 @default.
• W1773104009 cites W2116137883 @default.
• W1773104009 cites W2116522612 @default.
• W1773104009 cites W2117319600 @default.
• W1773104009 cites W2119652586 @default.
• W1773104009 cites W2120622159 @default.
• W1773104009 cites W2127096778 @default.
• W1773104009 cites W2128154577 @default.
• W1773104009 cites W2131992444 @default.
• W1773104009 cites W2135173569 @default.
• W1773104009 cites W2135188169 @default.
• W1773104009 cites W2138038262 @default.
• W1773104009 cites W2140879390 @default.
• W1773104009 cites W2142146745 @default.
• W1773104009 cites W2142330755 @default.
• W1773104009 cites W2143150258 @default.
• W1773104009 cites W2144074142 @default.
• W1773104009 cites W2144199857 @default.
• W1773104009 cites W2147516935 @default.
• W1773104009 cites W2151438250 @default.
• W1773104009 cites W2153245849 @default.
• W1773104009 cites W2156236968 @default.
• W1773104009 cites W2163176059 @default.
• W1773104009 cites W2167178283 @default.
• W1773104009 cites W2171726351 @default.
• W1773104009 cites W2287623303 @default.
• W1773104009 cites W4243575454 @default.
• W1773104009 doi "https://doi.org/10.1128/iai.00634-15" @default.
• W1773104009 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4567616" @default.
• W1773104009 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26195553" @default.
• W1773104009 hasPublicationYear "2015" @default.
• W1773104009 type Work @default.
• W1773104009 sameAs 1773104009 @default.
• W1773104009 citedByCount "28" @default.
• W1773104009 countsByYear W17731040092016 @default.
• W1773104009 countsByYear W17731040092017 @default.
• W1773104009 countsByYear W17731040092018 @default.
• W1773104009 countsByYear W17731040092019 @default.
• W1773104009 countsByYear W17731040092020 @default.
• W1773104009 countsByYear W17731040092021 @default.
• W1773104009 countsByYear W17731040092022 @default.
• W1773104009 countsByYear W17731040092023 @default.
• W1773104009 crossrefType "journal-article" @default.
• W1773104009 hasAuthorship W1773104009A5043254243 @default.
• W1773104009 hasAuthorship W1773104009A5082003915 @default.
• W1773104009 hasBestOaLocation W17731040091 @default.
• W1773104009 hasConcept C10389963 @default.
• W1773104009 hasConcept C104317684 @default.
• W1773104009 hasConcept C115811362 @default.
• W1773104009 hasConcept C136449434 @default.
• W1773104009 hasConcept C147483822 @default.
• W1773104009 hasConcept C155292618 @default.
• W1773104009 hasConcept C203014093 @default.

• next