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- W1773279845 abstract "Abstract Background The development and regression of corpus luteum (CL) is characterized by an intense angiogenesis and angioregression accompanied by luteal tissue and extracellular matrix (ECM) remodelling. Vascular Endothelial Growth Factor (VEGF) is the main regulator of angiogenesis, promoting endothelial cell mitosis and differentiation. After the formation of neovascular tubes, the remodelling of ECM is essential for the correct development of CL, particularly by the action of specific class of proteolytic enzymes known as matrix metalloproteinases (MMPs). During luteal regression, characterized by an apoptotic process and successively by an intense ECM and luteal degradation, the activation of Ca ++ /Mg ++ -dependent endonucleases and MMPs activity are required. The levels of expression and activity of VEGF, MMP-2 and -9, and Ca ++ /Mg ++ -dependent endonucleases throughout the oestrous cycle and at pregnancy were analyzed. Results Different patterns of VEGF, MMPs and Ca ++ /Mg ++ -dependent endonuclease were observed in swine CL during different luteal phases and at pregnancy. Immediately after ovulation, the highest levels of VEGF mRNA/protein and MMP-9 activity were detected. On days 5–14 after ovulation, VEGF expression and MMP-2 and -9 activities are at basal levels, while Ca ++ /Mg ++ -dependent endonuclease levels increased significantly in relation to day 1. Only at luteolysis (day 17), Ca ++ /Mg ++ -dependent endonuclease and MMP-2 spontaneous activity increased significantly. At pregnancy, high levels of MMP-9 and VEGF were observed. Conclusion Our findings, obtained from a precisely controlled in vivo model of CL development and regression, allow us to determine relationships among VEGF, MMPs and endonucleases during angiogenesis and angioregression. Thus, CL provides a very interesting model for studying factors involved in vascular remodelling." @default.
- W1773279845 created "2016-06-24" @default.
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- W1773279845 date "2006-11-30" @default.
- W1773279845 modified "2023-09-25" @default.
- W1773279845 title "Gelatinases, endonuclease and Vascular Endothelial Growth Factor during development and regression of swine luteal tissue" @default.
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- W1773279845 doi "https://doi.org/10.1186/1471-213x-6-58" @default.
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